Evolution: structural and functional diversity of cadherin at the adherens junction.

Evolution: structural and functional diversity of cadherin at the adherens junction.
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DOI:
10.1083/jcb.201008173
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发表时间:
2011-06-27
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Takeichi M
Takeichi M
中科院分区:
其他
文献类型:
--
作者:
Oda H;Takeichi M

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细胞间的黏附对多细胞生物的进化至关重要。事实上,动物的形态发生需要坚固而灵活的细胞间粘连,这种粘连是由亚细胞结构如粘附连接(AJ)介导的。AJs的一个关键成分是经典的钙粘蛋白,这是一组跨膜蛋白,在许多动物物种中维持动态的细胞-细胞关联。钙粘蛋白结构和功能的进化重建为理解动物形态发生机制的多样性提供了一个全面的框架。
Adhesion between cells is essential to the evolution of multicellularity. Indeed, morphogenesis in animals requires firm but flexible intercellular adhesions that are mediated by subcellular structures like the adherens junction (AJ). A key component of AJs is classical cadherins, a group of transmembrane proteins that maintain dynamic cell–cell associations in many animal species. An evolutionary reconstruction of cadherin structure and function provides a comprehensive framework with which to appreciate the diversity of morphogenetic mechanisms in animals.
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