Evolution: structural and functional diversity of cadherin at the adherens junction.
Evolution: structural and functional diversity of cadherin at the adherens junction.
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DOI:
10.1083/jcb.201008173
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发表时间:
2011-06-27
期刊:
影响因子:
--
通讯作者:
Takeichi M
中科院分区:
文献类型:
--
作者:
Oda H;Takeichi M
Adhesion between cells is essential to the evolution of multicellularity. Indeed, morphogenesis in animals requires firm but flexible intercellular adhesions that are mediated by subcellular structures like the adherens junction (AJ). A key component of AJs is classical cadherins, a group of transmembrane proteins that maintain dynamic cell–cell associations in many animal species. An evolutionary reconstruction of cadherin structure and function provides a comprehensive framework with which to appreciate the diversity of morphogenetic mechanisms in animals.
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