OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms.
OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms.
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Olig2在小儿星形细胞和室室肿瘤中差异表达。
DOI：
10.1007/s11060-010-0509-x
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发表时间：
2011-09
影响因子：
3.9
通讯作者：
Vandenberg, Scott
中科院分区：
文献类型：
--
作者：
Otero, Jose Javier;Rowitch, David;Vandenberg, Scott
bHLH转录因子，OLIG 2，普遍表达于成人胶质瘤，作为少突胶质细胞发育的主要因子，在低级别少突胶质细胞肿瘤中表达水平最高。此外，在遗传相关的小鼠模型中，它是高级别星形细胞瘤形成的功能所需。儿童神经胶质瘤具有与相应的成人肿瘤不同的基因组谱，因此，在特定肿瘤类型中，OLIG 2在非少突胶质细胞儿童神经胶质瘤中的表达没有得到很好的记录。在本研究中，90例非少突胶质细胞小儿神经胶质瘤中的OLIG 2表达模式从室管膜瘤（细胞性和粗细胞性）中的极低水平到毛细胞性星形细胞瘤和弥漫型星形细胞瘤（WHO II-IV级）中的高水平不等。在双标记的情况下，胶质母细胞瘤具有最高百分比的表达OLIG 2的细胞，其也是Ki-67阳性的（平均值= 16.3%），而毛细胞性星形细胞瘤WHO I级和星形细胞瘤WHO II级具有最低百分比（分别为0.9%和1%）;弥漫型星形细胞瘤（WHO II-III级）中的大多数Ki-67阳性细胞也是OLIG 2阳性的（92-94%）。与各种类型的儿科星形细胞肿瘤相反，所有WHO II级室管膜瘤，无论起源部位如何，均显示最低限度的OLIG 2表达，表明OLIG 2在儿科胶质瘤中的功能是细胞谱系依赖性的。本文的在线版本（doi：10.1007/s11060-010-0509-x）包含补充材料，可供授权用户使用。
The bHLH transcription factor, OLIG2, is universally expressed in adult human gliomas and, as a major factor in the development of oligodendrocytes, is expressed at the highest levels in low-grade oligodendroglial tumors. In addition, it is functionally required for the formation of high-grade astrocytomas in a genetically relevant murine model. The pediatric gliomas have genomic profiles that are different from the corresponding adult tumors and accordingly, the expression of OLIG2 in non-oligodendroglial pediatric gliomas is not well documented within specific tumor types. In the current study, the pattern of OLIG2 expression in a spectrum of 90 non-oligodendroglial pediatric gliomas varied from very low levels in the ependymomas (cellular and tanycytic) to high levels in pilocytic astrocytoma, and in the diffuse-type astrocytic tumors (WHO grades II–IV). With dual-labeling, glioblastoma had the highest percentage of OLIG2 expressing cells that were also Ki-67 positive (mean = 16.3%) whereas pilocytic astrocytoma WHO grade I and astrocytoma WHO grade II had the lowest (0.9 and 1%, respectively); most of the Ki-67 positive cells in the diffuse-type astrocytomas (WHO grade II–III) were also OLIG2 positive (92–94%). In contrast to the various types of pediatric astrocytic tumors, all ependymomas WHO grade II, regardless of site of origin, showed at most minimal OLIG2 expression, suggesting that OLIG2 function in pediatric gliomas is cell lineage dependent. The online version of this article (doi:10.1007/s11060-010-0509-x) contains supplementary material, which is available to authorized users.
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DOI：
10.1073/pnas.011404098
发表时间：
2001-01-02
影响因子：
11.1
作者：
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通讯作者：
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作者：
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