Targetability of the neurovascular unit in inflammatory diseases of the central nervous system.
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system.
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DOI：
10.1111/imr.13121
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发表时间：
2022-10
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
--
作者：
血脑屏障（BBB）是将外周与中枢神经系统（CNS）分隔开的选择性渗透屏障。血脑屏障限制了大多数物质流入和流出中枢神经系统，包括许多可用作有效治疗的药物。血脑屏障通透性由几个细胞调节，这些细胞统称为神经血管单位（NVU）。NVU由专门的CNS内皮细胞（EC）、周细胞、星形胶质细胞、小胶质细胞和神经元组成。CNS EC通过紧密连接保持复杂的“密封”，形成BBB;这些紧密连接的破坏导致BBB破坏。周细胞控制毛细血管内的血管流动，并帮助维持基底层。星形胶质细胞控制大部分已经移动超出CNS EC层的物质的流动，并且可以在炎症条件下形成次级屏障。小胶质细胞在NVU的边缘寻找有害物质。神经元活动也在BBB的维持中起作用。由于星形胶质细胞、周细胞、小胶质细胞和神经元都能够调节BBB的渗透性，因此低估NVU每个成员的复杂贡献将潜在地揭示用于将神经疗法递送至CNS的新颖且有效的方法。
The blood–brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent therapies. BBB permeability is modulated by several cells that are collectively called the neurovascular unit (NVU). The NVU consists of specialized CNS endothelial cells (ECs), pericytes, astrocytes, microglia, and neurons. CNS ECs maintain a complex “seal” via tight junctions, forming the BBB; breakdown of these tight junctions leads to BBB disruption. Pericytes control the vascular flow within capillaries and help maintain the basal lamina. Astrocytes control much of the flow of material that has moved beyond the CNS EC layer and can form a secondary barrier under inflammatory conditions. Microglia survey the border of the NVU for noxious material. Neuronal activity also plays a role in the maintenance of the BBB. Since astrocytes, pericytes, microglia, and neurons are all able to modulate the permeability of the BBB, understating the complex contributions of each member of the NVU will potentially uncover novel and effective methods for delivery of neurotherapies to the CNS.
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影响因子：
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作者：
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DOI：
10.3390/molecules23092371
发表时间：
2018-09-17
期刊：
Molecules (Basel, Switzerland)
影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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