Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI.
Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI.
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DOI：
10.1002/mrm.21627
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发表时间：
2008-08
影响因子：
3.3
通讯作者：
Ge, Yulin
中科院分区：
文献类型：
--
作者：
Lu, Hanzhang;Ge, Yulin
脑静脉氧合的非侵入性测量可以作为一种工具，更好地理解功能磁共振信号和脑氧稳态的临床评价。在这项研究中，一种新的技术，T2-弛豫下自旋标记（TRUST）磁共振成像，开发来估计静脉血管中的氧合。该方法利用自旋标记原理来自动分离纯血液信号，其中使用流动不敏感的T2准备脉冲来确定T2弛豫时间。然后使用校准图将血液T2转换为血氧。在体内实验中，健康志愿者（n=24）矢状窦的基线静脉氧合为64.8±6.3%。重现性研究表明，试验间的标准差为2.0± 1.1%。研究了重复时间和反转时间的选择对结果的影响。使用各种生理挑战进一步测试TRUST技术。高碳酸血症导致静脉氧合增加13.8± 1.1%。另一方面，摄入咖啡因导致氧合减少7.0± 1.8%。静脉注射造影剂（Gd-DTPA，0.1mmol/kg）使静脉血T2降低11.2ms。TRUST MRI是定量评估脑中血氧的有用技术。
Non-invasive measurement of cerebral venous oxygenation can serve as a tool for better understanding fMRI signals and for clinical evaluation of brain oxygen homeostasis. In this study, a novel technique, T2-Relaxation-Under-Spin-Tagging (TRUST) MRI, is developed to estimate oxygenation in venous vessels. This method utilizes the spin labeling principle to automatically isolate pure blood signals, from which T2 relaxation times are determined using flow-insensitive T2-preparation pulses. The blood T2 is then converted to blood oxygenation using a calibration plot. In vivo experiments gave a baseline venous oxygenation of 64.8±6.3% in sagittal sinus in healthy volunteers (n=24). Reproducibility studies demonstrated that the standard deviation across trials was 2.0±1.1%. The effects of repetition time and inversion time selections were investigated. The TRUST technique was further tested using various physiologic challenges. Hypercapnia induced an increase in venous oxygenation by 13.8± 1.1%. On the other hand, caffeine ingestion resulted in a decrease in oxygenation by 7.0±1.8%. Contrast agent infusion (Gd-DTPA, 0.1 mmol/kg) reduced venous blood T2 by 11.2ms. TRUST MRI is a useful technique for quantitative assessment of blood oxygenation in the brain.
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影响因子：
5.7
作者：
Mulderink, TA;Gitelman, DR;Parrish, TB
通讯作者：
Parrish, TB
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
3.3
作者：
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通讯作者：
NISHIMURA, DG
影响因子：
3.3
作者：
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通讯作者：
Yablonskiy, Dmitriy A.
影响因子：
4.4
作者：
Lu, HZ;Nagae-Poetscher, LM;van Zijl, PCM
通讯作者：
van Zijl, PCM