Clinical Characteristics Associated with Bacterial Bloodstream Coinfection in COVID-19.
Clinical Characteristics Associated with Bacterial Bloodstream Coinfection in COVID-19.
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DOI：
10.1007/s40121-022-00636-6
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发表时间：
2022-06
影响因子：
5.4
通讯作者：
Rybak, Michael J.
中科院分区：
文献类型：
--
作者：
Rebold, Nicholas;Alosaimy, Sara;Morrisette, Taylor;Holger, Dana;Lagnf, Abdalhamid M.;Ansari, Iman;Belza, Ana C.;Cheaney, Laura;Hussain, Huzaifa;Herbin, Shelbye R.;Abdul-Mutakabbir, Jacinda;Carron, Caitlin;Sandhu, Avnish;Chopra, Teena;Rybak, Michael J.
COVID-19中的不适当使用抗生素是由于假定的细菌共同感染的治疗，以区分Covid-19与Covid-19与细菌共感染或血液感染受到限制。
我们进行了一项回顾性队列研究，对595例Covid-19患者，在2020年3月8日至2020年4月4日之间接受了与细菌血液共感染相关的因素（BSI），主要结果是与BSI相关的任何特征。比较了真正的BSI（n = 25）和所有其他Covid-19病例（n = 570）之间的感兴趣变量（n = 570）。
发烧（> 38°C）（作为COVID-19症状）在True BSI（n = 25）和所有其他COVID-19患者（n = 570）（p = 0.93）之间没有差异，尽管这是急诊室（ED）入院的原因（p = 0.01）（p = 0.01）。纳入与真实的BSI相关（ED原因：OR = 3.27，P <0.01; Covid-19症状：OR = 2.69，P = 0.03）在多变量逻辑回归上高（15-19.9×109/L）白细胞（WBC）的录音率也更高。重要。在28天内，在真实的BSI中，30天的死亡率（p <0.01）（p = 0.34）。
COVID-19中的True BSI与神经系统符号和不重要的WBC相关，并导致总体上更高的30天死亡率和较差的患者结局。
在线版本包含的补充材料可获得10.1007/S40121-022-00636-6。
Inappropriate antibiotic use in COVID-19 is often due to treatment of presumed bacterial coinfection. Predictive factors to distinguish COVID-19 from COVID-19 with bacterial coinfection or bloodstream infection are limited. We conducted a retrospective cohort study of 595 COVID-19 patients admitted between March 8, 2020, and April 4, 2020, to describe factors associated with a bacterial bloodstream coinfection (BSI). The primary outcome was any characteristic associated with BSI in COVID-19, with secondary outcomes including 30-day mortality and days of antibiotic therapy (DOT) by antibiotic consumption (DOT/1000 patient-days). Variables of interest were compared between true BSI (n = 25) and all other COVID-19 cases (n = 570). A secondary comparison was performed between positive blood cultures with true BSI (n = 25) and contaminants (n = 33) on antibiotic use. Fever (> 38 °C) (as a COVID-19 symptom) was not different between true BSI (n = 25) and all other COVID-19 patients (n = 570) (p = 0.93), although it was different as a reason for emergency department (ED) admission (p = 0.01). Neurological symptoms (ED reason or COVID-19 symptom) were significantly higher in the true BSI group (p < 0.01, p < 0.01) and were independently associated with true BSI (ED reason: OR = 3.27, p < 0.01; COVID-19 symptom: OR = 2.69, p = 0.03) on multivariate logistic regression. High (15–19.9 × 109/L) white blood cell (WBC) count at admission was also higher in the true BSI group (p < 0.01) and was independently associated with true BSI (OR = 2.56, p = 0.06) though was not statistically significant. Thirty-day mortality was higher among true BSI (p < 0.01). Antibiotic consumption (DOT/1000 patient-days) between true BSI and contaminants was not different (p = 0.34). True bloodstream coinfection was 4.2% (25/595) over the 28-day period. True BSI in COVID-19 was associated with neurological symptoms and nonsignificant higher WBC, and led to overall higher 30-day mortality and worse patient outcomes. The online version contains supplementary material available at 10.1007/s40121-022-00636-6.
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DOI：
10.1016/j.cmi.2020.07.016
发表时间：
2020-12
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Langford BJ;So M;Raybardhan S;Leung V;Westwood D;MacFadden DR;Soucy JR;Daneman N
通讯作者：
Daneman N
影响因子：
3.5
作者：
Miyagami, Taiju;Uehara, Yuki;Naito, Toshio
通讯作者：
Naito, Toshio
DOI：
10.1016/j.cmi.2020.07.041
发表时间：
2021-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Garcia-Vidal C;Sanjuan G;Moreno-García E;Puerta-Alcalde P;Garcia-Pouton N;Chumbita M;Fernandez-Pittol M;Pitart C;Inciarte A;Bodro M;Morata L;Ambrosioni J;Grafia I;Meira F;Macaya I;Cardozo C;Casals C;Tellez A;Castro P;Marco F;García F;Mensa J;Martínez JA;Soriano A;COVID-19 Researchers Group
通讯作者：
COVID-19 Researchers Group
冠状病毒疾病 2019（COVID-19）对医疗保健相关感染的影响
影响因子：
11.8
作者：
Baker, Meghan A.;Sands, Kenneth E.;Perlin, Jonathan B.
通讯作者：
Perlin, Jonathan B.
影响因子：
11.8
作者：
Bhatt, Pinki J.;Shiau, Stephanie;Narayanan, Navaneeth
通讯作者：
Narayanan, Navaneeth