Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study.
Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study.
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DOI：
10.1016/j.cmi.2020.07.041
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
COVID-19 Researchers Group
中科院分区：
文献类型：
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作者：
Garcia-Vidal C;Sanjuan G;Moreno-García E;Puerta-Alcalde P;Garcia-Pouton N;Chumbita M;Fernandez-Pittol M;Pitart C;Inciarte A;Bodro M;Morata L;Ambrosioni J;Grafia I;Meira F;Macaya I;Cardozo C;Casals C;Tellez A;Castro P;Marco F;García F;Mensa J;Martínez JA;Soriano A;COVID-19 Researchers Group
描述2019冠状病毒病（COVID-19）住院患者发生合并感染和重复感染的负担、流行病学和结局。我们对因COVID-19（2020年2月28日至4月22日）在巴塞罗那医院诊所住院≥48小时并出院或死亡的所有连续患者进行了一项观察性队列研究。我们描述了人口统计学、流行病学、实验室和微生物学结果，以及从电子健康记录中检索到的结果数据。在总共989名连续的COVID-19患者中，72名（7.2%）有88例其他微生物学确认的感染：74例细菌感染，7例真菌感染和7例病毒感染。COVID-19诊断时的社区获得性合并感染并不常见（31/989，3.1%），主要由肺炎链球菌和金黄色葡萄球菌引起。共有51例医院获得性细菌双重感染，主要由铜绿假单胞菌和大肠埃希菌引起，43例患者（4.7%）被诊断，从入院到双重感染诊断的平均（SD）时间为10.6（6.6）天。总死亡率为9.8%（97/989）。社区获得性合并感染和医院获得性双重感染的患者预后更差。在COVID-19诊断时合并感染并不常见。少数患者在住院期间发生双重感染。这些发现与其他病毒大流行的发现不同。由于它与COVID-19住院患者有关，这些发现可能对确定经验性抗菌治疗或管理策略的作用至关重要。
To describe the burden, epidemiology and outcomes of co-infections and superinfections occurring in hospitalized patients with coronavirus disease 2019 (COVID-19). We performed an observational cohort study of all consecutive patients admitted for ≥48 hours to the Hospital Clinic of Barcelona for COVID-19 (28 February to 22 April 2020) who were discharged or dead. We describe demographic, epidemiologic, laboratory and microbiologic results, as well as outcome data retrieved from electronic health records. Of a total of 989 consecutive patients with COVID-19, 72 (7.2%) had 88 other microbiologically confirmed infections: 74 were bacterial, seven fungal and seven viral. Community-acquired co-infection at COVID-19 diagnosis was uncommon (31/989, 3.1%) and mainly caused by Streptococcus pneumoniae and Staphylococcus aureus. A total of 51 hospital-acquired bacterial superinfections, mostly caused by Pseudomonas aeruginosa and Escherichia coli, were diagnosed in 43 patients (4.7%), with a mean (SD) time from hospital admission to superinfection diagnosis of 10.6 (6.6) days. Overall mortality was 9.8% (97/989). Patients with community-acquired co-infections and hospital-acquired superinfections had worse outcomes. Co-infection at COVID-19 diagnosis is uncommon. Few patients developed superinfections during hospitalization. These findings are different compared to those of other viral pandemics. As it relates to hospitalized patients with COVID-19, such findings could prove essential in defining the role of empiric antimicrobial therapy or stewardship strategies.
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影响因子：
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作者：
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影响因子：
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