Detrimental impact of hyperlipidemia on the peripheral nervous system: A novel target of medical epidemiological and fundamental research study.
Detrimental impact of hyperlipidemia on the peripheral nervous system: A novel target of medical epidemiological and fundamental research study.
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DOI：
10.3969/j.issn.1673-5374.2012.05.011
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发表时间：
2012-02-15
影响因子：
6.1
通讯作者：
Xiong K
中科院分区：
文献类型：
--
作者：
Wu S;Cao X;He R;Xiong K
近年来，对周围神经病变病因学的流行病学研究表明，高脂血症是一种新的危险因素。血脂水平被证实与许多周围神经病变的发生有关，包括轴突远端多发性神经病、视力和听力损失、运动神经系统病变和交感神经系统功能障碍。此外，不同的脂质成分，如胆固醇，甘油三酯和脂蛋白参与这些神经病变的发病机制。本文就高脂血症对周围神经系统的影响及其与周围神经病变的关系作一综述。此外，详细的讨论集中在明确的机制，高血压引起的周围神经病变在这里。这些机制，包括细胞内氧化应激，炎症病变，缺血和局部脂质代谢失调，共享的途径和相互作用。此外，我们检查了目前的临床试验，以预防和治疗高脂血症引起的周围神经病变的信息，与未来的研究方向的预测性讨论。
Recently, epidemiological studies on the etiology of peripheral neuropathies have revealed that hyperlipidemia is a novel risk factor. Plasma lipid levels were confirmed to be associated with the incidence of many peripheral neuropathies including axonal distal polyneuropathy, vision and hearing loss, motor nerve system lesions and sympathetic nerve system dysfunction. Moreover, different lipid components such as cholesterol, triacylglycerols and lipoprotein are involved in the pathogenesis of these neuropathies. This review aimed to discuss the effect of hyperlipidemia on the peripheral nervous system and its association with peripheral neuropathies. Furthermore, a detailed discussion focusing on the explicit mechanisms related to hyperlipidemia-induced peripheral neuropathies is presented here. These mechanisms, including intracellular oxidative stress, inflammatory lesions, ischemia and dysregulation of local lipid metabolism, share pathways and interact mutually. In addition, we examined current information on clinical trials to prevent and treat peripheral neuropathies caused by hyperlipidemia, with a predictive discussion regarding the orientation of future investigations.
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影响因子：
4.4
作者：
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通讯作者：
Redmond, HP
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