Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility.
Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility.
复制标题
DOI：
10.1016/j.pbiomolbio.2012.07.013
复制
发表时间：
2012-10
影响因子：
3.8
通讯作者：
Tung L
中科院分区：
文献类型：
--
作者：
Blazeski A;Zhu R;Hunter DW;Weinberg SH;Zambidis ET;Tung L
自从人类诱导多能干细胞衍生的心肌细胞（hiPSC-CM）的首次描述以来，这些细胞因其在患者特异性分析和治疗中的潜在用途而引起了极大的兴趣。此外，hiPSC-CM可以来源于来自患有特定心脏疾病的患者的供体细胞，使得能够在体外建立人类疾病模型用于机制研究和治疗药物评估。然而，充分了解他们的电生理和收缩功能是必要的，才能实现这种潜力。在这里，我们回顾这一新兴领域从功能的角度来看，特别强调跳动率，动作电位，离子电流，多细胞传导，钙处理和收缩。我们进一步回顾了现有的hiPSC-CM疾病模型，概括了遗传性心肌疾病。
Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific cardiac disorders, enabling in vitro human disease models for mechanistic study and therapeutic drug assessment. However, a full understanding of their electrophysiological and contractile function is necessary before this potential can be realized. Here, we review this emerging field from a functional perspective, with particular emphasis on beating rate, action potential, ionic currents, multicellular conduction, calcium handling and contraction. We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease.
登录
查看更多内容
影响因子：
3.8
作者：
Cohen JD;Babiarz JE;Abrams RM;Guo L;Kameoka S;Chiao E;Taunton J;Kolaja KL
通讯作者：
Kolaja KL
影响因子：
23.9
作者：
Burridge, Paul W.;Keller, Gordon;Gold, Joseph D.;Wu, Joseph C.
通讯作者：
Wu, Joseph C.
影响因子：
3.7
作者：
Fu JD;Rushing SN;Lieu DK;Chan CW;Kong CW;Geng L;Wilson KD;Chiamvimonvat N;Boheler KR;Wu JC;Keller G;Hajjar RJ;Li RA
通讯作者：
Li RA
影响因子：
--
作者：
Guo, Liang;Qian, Jian-Yong;Kolaja, Kyle L.
通讯作者：
Kolaja, Kyle L.
DOI：
10.1016/j.pbiomolbio.2012.07.012
发表时间：
2012-10
影响因子：
3.8
作者：
Blazeski A;Zhu R;Hunter DW;Weinberg SH;Boheler KR;Zambidis ET;Tung L
通讯作者：
Tung L