Oh my gut! Is the microbial origin of neurodegenerative diseases real?
Oh my gut! Is the microbial origin of neurodegenerative diseases real?
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DOI：
10.1128/iai.00437-22
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发表时间：
2023-10-17
影响因子：
3.1
通讯作者：
Czyz, Daniel M.
中科院分区：
文献类型：
--
作者：
Walker, Alyssa;Czyz, Daniel M.
关键词：
对于神经变性蛋白质构象疾病（PCD），例如阿尔茨海默病或帕金森病，没有治愈或有效的治疗，主要是因为这些疾病的病因仍然难以捉摸。最近的数据表明，肠道微生物组成的独特变化与这些疾病有关;然而，我们目前对细菌在PCD发病机制中的作用的理解受到与特定微生物组（如肠道，口腔或阴道微生物群）相关的微生物群落复杂性的阻碍。这些特定微生物组的组成被认为是受感染，饮食，生活方式和抗生素等因素影响的独特指纹。所有这些因素也会影响神经退行性疾病的严重程度。大多数揭示微生物贡献的研究都是相关的，并且各种模型，包括蠕虫，苍蝇和小鼠，正在被用来破译可能影响疾病发作和进展的单个微生物的作用。最近的证据表明，跨模式生物和人类之间的存在的革兰氏阴性肠道致病菌和PCD的发病机制呈正相关。虽然这些相关性研究并没有提供一个机械解释，但它们确实揭示了贡献细菌物种，并为进一步研究提供了重要基础。与微生物对PCD的贡献相关的潜在问题之一是抗生素耐药性和抗生素管理不善的流行率越来越高，最终选择蛋白毒性细菌，特别是已知具有内在耐药性的革兰氏阴性菌。在这篇综述中，我们总结了已知的个别微生物对PCD的贡献和增加抗菌药物耐药性的潜在影响。
There is no cure or effective treatment for neurodegenerative protein conformational diseases (PCDs), such as Alzheimer’s or Parkinson’s diseases, mainly because the etiology of these diseases remains elusive. Recent data suggest that unique changes in the gut microbial composition are associated with these ailments; however, our current understanding of the bacterial role in the pathogenesis of PCDs is hindered by the complexity of the microbial communities associated with specific microbiomes, such as the gut, oral, or vaginal microbiota. The composition of these specific microbiomes is regarded as a unique fingerprint affected by factors such as infections, diet, lifestyle, and antibiotics. All of these factors also affect the severity of neurodegenerative diseases. The majority of studies that reveal microbial contribution are correlational, and various models, including worm, fly, and mouse, are being utilized to decipher the role of individual microbes that may affect disease onset and progression. Recent evidence from across model organisms and humans shows a positive correlation between the presence of gram-negative enteropathogenic bacteria and the pathogenesis of PCDs. While these correlational studies do not provide a mechanistic explanation, they do reveal contributing bacterial species and provide an important basis for further investigation. One of the lurking concerns related to the microbial contribution to PCDs is the increasing prevalence of antibiotic resistance and poor antibiotic stewardship, which ultimately select for proteotoxic bacteria, especially the gram-negative species that are known for intrinsic resistance. In this review, we summarize what is known about individual microbial contribution to PCDs and the potential impact of increasing antimicrobial resistance.
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影响因子：
12.3
作者：
Bedarf JR;Hildebrand F;Coelho LP;Sunagawa S;Bahram M;Goeser F;Bork P;Wüllner U
通讯作者：
Wüllner U
影响因子：
4.8
作者：
Akbari E;Asemi Z;Daneshvar Kakhaki R;Bahmani F;Kouchaki E;Tamtaji OR;Hamidi GA;Salami M
通讯作者：
Salami M
影响因子：
5.3
作者：
Brouillette, Jonathan;Caillierez, Raphaelle;Buee, Luc
通讯作者：
Buee, Luc
影响因子：
4.8
作者：
Balczon, Ron;Morrow, K. Adam;Stevens, Troy
通讯作者：
Stevens, Troy
影响因子：
11.8
作者：
Boucher, Helen W.;Talbot, George H.;Bartlett, John
通讯作者：
Bartlett, John