Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial.
Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial.
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DOI：
10.3389/fnagi.2016.00256
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发表时间：
2016
影响因子：
4.8
通讯作者：
Salami M
中科院分区：
文献类型：
--
作者：
Akbari E;Asemi Z;Daneshvar Kakhaki R;Bahmani F;Kouchaki E;Tamtaji OR;Hamidi GA;Salami M
阿尔茨海默病（AD）与严重的认知障碍以及一些代谢缺陷相关。在动物模型中的少量研究表明益生菌和认知功能之间存在联系。这项随机、双盲和对照的临床试验在60名AD患者中进行，以评估益生菌补充剂对认知功能和代谢状态的影响。将患者随机分为两组（每组n = 30），分别给予牛奶（对照组）和益生菌混合物（益生菌组）治疗。益生菌添加组每天饮用含嗜酸乳杆菌、干酪乳杆菌、两歧双歧杆菌和发酵乳杆菌（各2 × 109 CFU/g）的益生菌乳200 ml，持续12周。治疗前后分别进行简易精神状态检查量表（MMSE）评分。采集治疗前和治疗后空腹血液样本，以确定相关标志物。经过12周的干预，与对照组（-5.03% ± 3.00）相比，益生菌治疗组（+27.90% ± 8.07）患者的MMSE评分显着改善（P <0.001）。此外，血浆丙二醛的变化（−22.01% ± 4.84 vs. +2.67% ± 3.86 μmol/L，P <0.001），血清超敏C反应蛋白（−17.61% ± 3.70 vs. +45.26% ± 3.50 μg/mL，P <0.001），评估-估计胰岛素抵抗的稳态模型（+28.84% ± 13.34 vs. +76.95% ± 24.60，P = 0.002），β细胞功能（+3.45% ± 10.91 vs. +75.62% ± 23.18，P = 0.001），血清甘油三酯（−20.29% ± 4.49 vs. −0.16% ± 5.24 mg/dL，P = 0.003）和定量胰岛素敏感性检查指数（−1.83 ± 1.26 vs. −4.66 ± 1.70，P = 0.006）与对照组相比差异显著。我们发现，益生菌治疗对氧化应激和炎症的其他生物标志物、空腹血糖和其他脂质特征没有显著影响。总的来说，目前的研究表明，益生菌消费12周对AD患者的认知功能和某些代谢状态有积极影响。临床试验注册：http：//www.irct.ir/，IRCT 201511305623 N60。
Alzheimer's disease (AD) is associated with severe cognitive impairments as well as some metabolic defects. Scant studies in animal models indicate a link between probiotics and cognitive function. This randomized, double-blind, and controlled clinical trial was conducted among 60 AD patients to assess the effects of probiotic supplementation on cognitive function and metabolic status. The patients were randomly divided into two groups (n = 30 in each group) treating with either milk (control group) or a mixture of probiotics (probiotic group). The probiotic supplemented group took 200 ml/day probiotic milk containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus fermentum (2 × 109 CFU/g for each) for 12 weeks. Mini-mental state examination (MMSE) score was recorded in all subjects before and after the treatment. Pre- and post-treatment fasting blood samples were obtained to determine the related markers. After 12 weeks intervention, compared with the control group (−5.03% ± 3.00), the probiotic treated (+27.90% ± 8.07) patients showed a significant improvement in the MMSE score (P <0.001). In addition, changes in plasma malondialdehyde (−22.01% ± 4.84 vs. +2.67% ± 3.86 μmol/L, P <0.001), serum high-sensitivity C-reactive protein (−17.61% ± 3.70 vs. +45.26% ± 3.50 μg/mL, P <0.001), homeostasis model of assessment-estimated insulin resistance (+28.84% ± 13.34 vs. +76.95% ± 24.60, P = 0.002), Beta cell function (+3.45% ± 10.91 vs. +75.62% ± 23.18, P = 0.001), serum triglycerides (−20.29% ± 4.49 vs. −0.16% ± 5.24 mg/dL, P = 0.003), and quantitative insulin sensitivity check index (−1.83 ± 1.26 vs. −4.66 ± 1.70, P = 0.006) in the probiotic group were significantly varied compared to the control group. We found that the probiotic treatment had no considerable effect on other biomarkers of oxidative stress and inflammation, fasting plasma glucose, and other lipid profiles. Overall, the current study demonstrated that probiotic consumption for 12 weeks positively affects cognitive function and some metabolic statuses in the AD patients. Clinical Trial Registration: http://www.irct.ir/, IRCT201511305623N60.
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影响因子：
5.6
作者：
Amemori T;Jendelova P;Ruzicka J;Urdzikova LM;Sykova E
通讯作者：
Sykova E
影响因子：
3.3
作者：
Davari, S.;Talaei, S. A.;Salami, M.
通讯作者：
Salami, M.
影响因子：
2.9
作者：
Drago, Lorenzo;Toscano, Marco;Mogna, Giovanni
通讯作者：
Mogna, Giovanni
影响因子：
3.3
作者：
Liang, S.;Wang, T.;Jin, F.
通讯作者：
Jin, F.
DOI：
10.1177/1740774515602688
发表时间：
2016-04
期刊：
Clinical trials (London, England)
影响因子：
--
作者：
Lachin JM
通讯作者：
Lachin JM