Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.
Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.
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DOI：
10.1016/j.ceb.2010.06.003
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发表时间：
2010-12
影响因子：
7.5
通讯作者：
Li R
中科院分区：
文献类型：
--
作者：
Pavelka N;Rancati G;Li R
当我们体内的细胞改变它们的基因组并发展成癌症时，我们将其归咎于基因组的不稳定性。当新物种征服了不适宜生存的环境时，我们将其归功于基因组进化。然而，从细胞的角度来看，这两个过程都是相同的基本生物学特性的结果-基因组和途径可塑性以及逃避死亡并获得生长优势的细胞的自然选择。在细胞水平上揭示基因组可塑性的后果不仅是理解物种进化的核心，而且对于破译重要的细胞生物学问题也至关重要，例如癌细胞如何出现以及病原体如何产生耐药性。除了众所周知的DNA序列突变的作用外，最近的证据表明，DNA拷贝数的变化以节段或整个染色体非整倍性的形式可以带来大的表型变异。虽然在适合整倍体细胞正常增殖的条件下通常是有害的，但非整倍化可能是一种频繁发生的遗传变化，使病原体或癌细胞能够逃避生理或药理学障碍。
When cells in our body change their genome and develop into cancer, we blame it on genome instability. When novel species conquer inhospitable environments, we credit it to genome evolution. From a cellular perspective, however, both processes are outcomes of the same fundamental biological properties – genome and pathway plasticity and the natural selection of cells that escape death and acquire growth advantages. Unraveling the consequences of genome plasticity at a cellular level is not only central to the understanding of species evolution but also crucial to deciphering important cell biological problems, such as how cancer cells emerge and how pathogens develop drug resistance. Aside from the well-known role of DNA sequence mutations, recent evidence suggests that changes in DNA copy numbers in the form of segmental or whole-chromosome aneuploidy can bring about large phenotypic variation. Although usually detrimental under conditions suitable for normal proliferation of euploid cells, aneuploidization may be a frequently occurring genetic change that enables pathogens or cancer cells to escape physiological or pharmacological roadblocks.
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影响因子：
21.3
作者：
Bakhoum, Samuel F.;Thompson, Sarah L.;Manning, Amity L.;Compton, Duane A.
通讯作者：
Compton, Duane A.
影响因子：
2.5
作者：
Bond, U;Neal, C;James, TC
通讯作者：
James, TC
DOI：
10.1073/pnas.0710370104
发表时间：
2007-12-26
影响因子：
11.1
作者：
Bean, James;Brennan, Cameron;Pao, William
通讯作者：
Pao, William
影响因子：
3.6
作者：
Selmecki, A;Bergmann, S;Berman, J
通讯作者：
Berman, J
DOI：
10.1007/bf00268670
发表时间：
1977-01-01
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
作者：
GORENSTEIN, C;WARNER, JR
通讯作者：
WARNER, JR