In-depth conversation: spectrum and kinetics of neuroimmune afferent pathways.
In-depth conversation: spectrum and kinetics of neuroimmune afferent pathways.
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DOI：
10.1016/j.bbi.2014.02.006
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Quan N
中科院分区：
文献类型：
--
作者：
Quan N
自从我在2008年对神经免疫通讯传入的最后一次回顾以来，这一领域已经有了实质性的增长。在基础科学层面，许多新的和令人兴奋的现象已经被描述，增加了免疫系统和神经系统之间的串扰的深度和复杂性。在翻译水平上，越来越多的证据表明，神经免疫相互作用可能是许多疾病状态的一个促成因素，也是一种有效的生理机制，可以协调健康个体或组织窘迫期间这两个系统的活动。此外，新的证据表明，神经免疫相互作用本质上是动态的：神经系统或免疫系统中的不同活动可能会影响它们之间的相互作用。在这篇综述中，我将尝试将多种多样的，有时是不同的，调查结果到一个修改后的概念框架，描述了一致性的神经免疫通信通过这两个系统之间的合作连接和功能障碍时，可能会出现不适当的串扰发生。
Since my last review on neuroimmune communication afferents in 2008, this area has witnessed substantial growth. At a basic science level, numerous new and exciting phenomena have been described, adding both depth and complexity to the crosstalk between the immune system and the nervous system. At a translational level, accumulating evidence indicates neuroimmune interaction could be a contributing factor for many disease states, as well as an effective physiological mechanism that coordinates the activities of these two systems in healthy individuals or during tissue distress. Furthermore, new evidence suggests neuroimmune interactions are inherently dynamic: varying activities in either the nervous system or the immune system could impact interactions between them. In this review I will attempt to integrate multifarious, and sometimes disparate, findings into a modified conceptual framework that describes the concordance of neuroimmune communication through the cooperative connection between these two systems and the dysfunction that may arise when their inappropriate crosstalk occurs.
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