Dynamic Functional Connectivity Within the Fronto-Limbic Network Induced by Intermittent Theta-Burst Stimulation: A Pilot Study
Dynamic Functional Connectivity Within the Fronto-Limbic Network Induced by Intermittent Theta-Burst Stimulation: A Pilot Study
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间歇性 Theta 爆发刺激引起的额边缘网络内的动态功能连接：一项试点研究
DOI：
10.3389/fnins.2019.00944
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发表时间：
2019-09
影响因子：
4.3
通讯作者：
Wang Jijun
中科院分区：
文献类型：
--
作者：
Tang Yingying;Jiao Xiong;Wang Junjie;Zhu Tianyuan;Zhou Jie;Qian Zhenying;Zhang Tianhong;Cui Huiru;Li Hui;Tang Xiaochen;Xu Lihua;Zhang Ling;Wei Yanyan;Sheng Jianhua;Liu Liu;Wang Jijun
目的近几十年来，经颅磁刺激(TMS)在神经认知研究和临床应用中的应用日益广泛。然而，目前尚不清楚刺激部位和部位相关功能网络对外部TMS操作的反应如何随时间动态变化。方法采用多节段TMS-fMRI联合实验，探讨TMS在额缘网络内的时空效应。10名健康志愿者在左侧前额叶背外侧皮质(DLPFC，MNI坐标[-44 36 20])的精确位置进行间歇性theta-Burst刺激(ITBS)，由个体结构MRI图像导航。每个参与者在ITBS前(TP1)、ITBS后即刻(TP2)和ITBS后15min(TP3)分别采集三个时段的静息状态fMRI图像。在额缘网络中选取74个感兴趣区，包括双侧额上回(SFG)、额中回(MidFG)、额下回(IFG)、眶回(Org)、扣带回(CG)和皮质下核(海马和杏仁核)。比较TP1、TP2和TP3之间的局部低频波动幅度(FALFF)和ROI-to-ROI功能连接性(FC)。结果在刺激部位即可观察到ITBS效应。与Tp1时相比，Tp2时左侧SFG与左侧背侧IFG之间以及左嘴IFG与右侧MidFG之间的FC增加(均为0.05)，而左侧组织内的FC降低。相对长期的ITBS效应传递时，左侧IFG和右侧杏仁核之间的FC降低，左侧MidFG和左侧ORG之间的FC增加，TP3时两侧IFG和ORG之间的FC降低(均为FDR-p；t；0.05)。同时，左侧SFG、MidFG、腹侧CG和IFG的平均fALF值在TP3时显著高于TP2(经Bonferroni校正后均为P<；0.05)。结论TMS和fMRI相结合，可以追踪额缘网络内TMS后效的时空动态变化。我们的发现表明，ITBS效应随着时间的推移而动态变化，从刺激部位的局部神经激活到额缘网络中连接的远程区域。
Purpose The utility of transcranial magnetic stimulation (TMS) has been growing rapidly in both neurocognitive studies and clinical applications in decades. However, it remains unclear how the responses of the stimulated site and the site-related functional network to the external TMS manipulation dynamically change over time. Methods A multi-session combining TMS-fMRI experiment was conducted to explore the spatiotemporal effects of TMS within the fronto-limbic network. Ten healthy volunteers were modulated by intermittent theta-burst stimulation (iTBS) at a precise site within the left dorsolateral prefrontal cortex (DLPFC, MNI coordinate [-44 36 20]), navigated by individual structural MRI image. Three-session resting-state fMRI images were acquired before iTBS (TP1), immediately after iTBS (TP2), and 15 min after iTBS (TP3) for each participant. Seventy-four regions of interests (ROIs) within the fronto-limbic network were chosen including the bilateral superior frontal gyrus (SFG), middle frontal gyrus (MidFG), inferior frontal gyrus (IFG), orbital gyrus (OrG), cingulate gyrus (CG), and subcortical nuclei (hippocampus and amygdala). Regional fractional amplitude of low-frequency fluctuation (fALFF) and ROI-to-ROI functional connectivity (FC) were compared among TP1, TP2, and TP3. Results The immediate iTBS effect was observed at the stimulated site. FC between the left dorsolateral SFG and left dorsal IFG and between the left rostral IFG and right MidFG increased at TP2 as compared to at TP1 (all FDR-p < 0.05), while FC within the left OrG decreased. The relatively long-term iTBS effect transmitted with decreased FC between the left IFG and right amygdala, increased FC between the left MidFG and left OrG, and decreased FC between bilateral IFG and OrG at TP3 than at TP1 (all FDR-p < 0.05). Meanwhile, mean fALFF values over the left SFG, MidFG, ventral CG, and IFG were significantly increased at TP3 as compared to those at TP2 (all p < 0.05 with Bonferroni correction). Conclusion By combining TMS and fMRI, it becomes possible to track the spatiotemporal dynamics of TMS after-effects within the fronto-limbic network. Our findings suggested that the iTBS effect dynamically changed over time from the local neural activation at the stimulated site to its connected remote regions within the fronto-limbic network.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
25.8
作者：
Lerman, Caryn;Gu, Hong;Loughead, James;Ruparel, Kosha;Yang, Yihong;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
25.8
作者：
Yinming Sun;F. Farzan;B. Mulsant;T. Rajji;P. Fitzgerald;M. Barr;J. Downar;W. Wong;D. Blumberger-D.-Blumb
通讯作者：
Yinming Sun;F. Farzan;B. Mulsant;T. Rajji;P. Fitzgerald;M. Barr;J. Downar;W. Wong;D. Blumberger-D.-Blumb
DOI：
10.1186/1757-1626-3-38
发表时间：
2010-01-28
期刊：
Cases journal
影响因子：
--
作者：
Tuli N
通讯作者：
Tuli N
影响因子：
3.7
作者：
Cho SS;Strafella AP
通讯作者：
Strafella AP