rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex.
rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex.
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DOI：
10.1371/journal.pone.0006725
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发表时间：
2009-08-21
期刊：
影响因子：
3.7
通讯作者：
Strafella AP
中科院分区：
文献类型：
--
作者：
Cho SS;Strafella AP
脑多巴胺参与运动、注意力、奖赏和学习的调节，在帕金森病、精神分裂症和药物成瘾中起重要作用。动物实验表明，脑刺激能够引起纹外区多巴胺能的显着变化。鉴于非侵入性脑刺激作为治疗神经和精神疾病的潜在工具的兴趣日益增长，研究前额叶皮层中多巴胺能功能的相互作用，特别是背外侧前额叶皮层（DLPFC）（9/46区）刺激对前额叶多巴胺（DA）的影响将是至关重要的。健康志愿者在左右DLPFC的10 Hz重复经颅磁刺激（rTMS）后，使用高亲和力DA D2受体放射性配体[11 C]FLB 457-PET进行研究。左侧DLPFC上的rTMS诱导同侧膝下前扣带回皮质（ACC）（BA 25/12）、膝前ACC（BA 32）和内侧眶额皮质（BA 11）中[11 C]FLB 457结合电位（BP）显著降低。右侧DLPFC rTMS后[11 C]FLB 457 BP无显著变化。据我们所知，这是第一个研究提供的证据，纹状体外DA调制后，急性rTMS DLPFC的影响仅限于内侧前额叶皮层的特定区域。[11 C]FLB 457-PET结合rTMS可以探索特定皮质神经网络的神经化学功能，并有助于确定TMS治疗不同神经和精神疾病的神经生物学作用。
Brain dopamine is implicated in the regulation of movement, attention, reward and learning and plays an important role in Parkinson's disease, schizophrenia and drug addiction. Animal experiments have demonstrated that brain stimulation is able to induce significant dopaminergic changes in extrastriatal areas. Given the up-growing interest of non-invasive brain stimulation as potential tool for treatment of neurological and psychiatric disorders, it would be critical to investigate dopaminergic functional interactions in the prefrontal cortex and more in particular the effect of dorsolateral prefrontal cortex (DLPFC) (areas 9/46) stimulation on prefrontal dopamine (DA). Healthy volunteers were studied with a high-affinity DA D2-receptor radioligand, [11C]FLB 457-PET following 10 Hz repetitive transcranial magnetic stimulation (rTMS) of the left and right DLPFC. rTMS on the left DLPFC induced a significant reduction in [11C]FLB 457 binding potential (BP) in the ipsilateral subgenual anterior cingulate cortex (ACC) (BA 25/12), pregenual ACC (BA 32) and medial orbitofrontal cortex (BA 11). There were no significant changes in [11C]FLB 457 BP following right DLPFC rTMS. To our knowledge, this is the first study to provide evidence of extrastriatal DA modulation following acute rTMS of DLPFC with its effect limited to the specific areas of medial prefrontal cortex. [11C]FLB 457-PET combined with rTMS may allow to explore the neurochemical functions of specific cortical neural networks and help to identify the neurobiological effects of TMS for the treatment of different neurological and psychiatric diseases.
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影响因子：
5.3
作者：
Aalto, S;Brück, A;Rinne, JO
通讯作者：
Rinne, JO
影响因子：
3.4
作者：
Bigliani, V;Mulligan, RS;Pilowsky, LS
通讯作者：
Pilowsky, LS
影响因子：
5.7
作者：
Gunn, RN;Lammertsma, AA;Cunningham, VJ
通讯作者：
Cunningham, VJ
影响因子：
4.7
作者：
Keck, ME;Welt, T;Sillaber, I
通讯作者：
Sillaber, I
DOI：
10.1080/10401230591002110
发表时间：
2005-07-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Isenberg, Keith;Downs, Dana;Kormos, Theresa C
通讯作者：
Kormos, Theresa C