Modeling a Circadian Surface
Modeling a Circadian Surface
复制标题
昼夜节律表面建模
DOI：
--
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发表时间：
2010
影响因子：
3.5
通讯作者：
M. Merrow
中科院分区：
文献类型：
--
作者：
T. Roenneberg;J. Rémi;M. Merrow
系统地改变粗神经孢子虫的T、τ和光周期的实验表明，传统的非参数和参数方法不能解释所有测试条件下的携带。作者已经开发了一种新的方法来理解夹带，它结合了旧范式的几个特征，但允许探索同步时钟的潜在机制，使从恒定条件到夹带状态的外推变得不必要。它基于昼夜节律综合响应特性（CIRC），不假设夹带是如何发生的（通过相移或速度变化）。它所假定的是，在夹带过程中，时钟的周期长度必须与授时体的周期长度相匹配。在CIRC的帮助下，可以通过改变3个参数来模拟所有授时条件的夹带：CIRC的形状和不对称性，以及时钟在稳定夹带下采用的假设内部周期长度（夹带下的τ: τE），以产生与授时数的特定相位关系（τE反映在时钟释放到恒定条件时的周期后效应中）。CIRC的几个参数使其易于建模。在这里，作者描述了神经孢子虫昼夜节律面建模的结果，并表明新方法可以解释和统一昼夜节律面的所有结果。CIRC的质量对于各自的夹带条件具有高度的系统性，并表明τE是夹带过程中的一个重要变量。结果还表明，尽管野生型菌株在恒定黑暗条件下的时间较短（~22 h），但在自然24 h周期下，其对夹带的调节能力较好。测量后效应的实验支持τE在夹带中起重要作用的预测。
Experiments that systematically varied T, τ, and photoperiod in Neurospora crassa revealed that the traditional nonparametric and parametric approaches could not explain entrainment for all of the tested conditions. The authors have developed a new approach to understanding entrainment that incorporates several features of the old paradigms but allows exploration of the underlying mechanisms in synchronized clocks, making extrapolations from constant conditions to entrained state unnecessary. It is based on a circadian integrated response characteristic (CIRC) that makes no assumptions about how entrainment occurs (by phase shifts or velocity changes). All it presumes is that, during entrainment, the clock’s cycle length must match that of the zeitgeber. With the help of the CIRC, entrainment to all zeitgeber conditions can be modeled by changing 3 parameters: the CIRC’s shape and asymmetry and an assumed internal cycle length (τ under entrainment: τ E) that the clock adopts under stable entrainment to produce a specific phase relationship to the zeitgeber (τE is reflected in a period aftereffect when clocks are released to constant conditions). The few parameters of the CIRC make it highly amenable to modeling. Here, the authors describe the results of modeling Neurospora’s circadian surface and show that the new approach can explain and unify all results of the circadian surface. The qualities of the CIRC are highly systematic for the respective entrainment condition and show that τE is an important variable in the entrainment process. The results also show that the wild-type strain is excellently tuned for entrainment under the natural 24-h cycle despite its shorter period (~22 h) in constant darkness. Experiments measuring aftereffects support the prediction that τE plays an important role in entrainment.
人类昼夜节律起搏器在整个主观一天中对光敏感，没有瞬变的证据。
DOI：
10.1152/ajpregu.1997.273.5.r1800
发表时间：
1997
期刊：
The American journal of physiology
影响因子：
--
作者：
Jewett,ME;Rimmer,DW;Duffy,JF;Klerman,EB;Kronauer,RE;Czeisler,CA
通讯作者：
Czeisler,CA
影响因子：
10.5
作者：
Belden, William J.;Larrondo, Luis F.;Dunlap, Jay C.
通讯作者：
Dunlap, Jay C.