Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients.

Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients.
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人类昼夜节律起搏器在整个主观一天中对光敏感,没有瞬变的证据。

DOI:
10.1152/ajpregu.1997.273.5.r1800
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发表时间:
1997
期刊:
The American journal of physiology
影响因子:
--
通讯作者:
Czeisler,CA
Czeisler,CA
中科院分区:
--
文献类型:
--
作者:
Jewett,ME;Rimmer,DW;Duffy,JF;Klerman,EB;Kronauer,RE;Czeisler,CA

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在43名年轻男性中进行了五十六次重置试验,在非常昏暗的光线(10-15 lx)背景下使用三个周期的强光(10,000 lx)刺激。评估这些试验的相位响应曲线(PRC)是否存在光不敏感性的“死区”,并与另一个使用150 lx背景的三周期PRC进行比较。为了评估光刺激后可能的瞬变,试验分为43个稳态试验,发生在几个基线天后,和13个召唤试验,发生在前一个重置试验后立即。我们发现:1)明亮的光诱导相移整个主观的一天,没有明显的死区;2)没有证据表明,在恒定的常规评估的拟合温度最低值1-2天后完成的重置刺激的瞬态;和3)的背景室光的时间调制的重置响应明亮的光。这些数据表明,人类的昼夜节律起搏器是敏感的光在几乎所有的昼夜节律阶段,这意味着整个24小时模式的曝光有助于夹带。
Fifty-six resetting trials were conducted across the subjective day in 43 young men using a three-cycle bright-light (∼10,000 lx) stimulus against a background of very dim light (10–15 lx). The phase-response curve (PRC) to these trials was assessed for the presence of a “dead zone” of photic insensitivity and was compared with another three-cycle PRC that had used a background of ∼150 lx. To assess possible transients after the light stimulus, the trials were divided into 43steady-statetrials, which occurred after several baseline days, and 13consecutivetrials, which occurred immediately after a previous resetting trial. We found that1) bright light induces phase shifts throughout subjective day with no apparent dead zone;2) there is no evidence of transients in constant routine assessments of the fitted temperature minimum 1–2 days after completion of the resetting stimulus; and3) the timing of background room light modulates the resetting response to bright light. These data indicate that the human circadian pacemaker is sensitive to light at virtually all circadian phases, implying that the entire 24-h pattern of light exposure contributes to entrainment.
光对人体昼夜节律起搏器的影响。
DOI: 10.1002/9780470514597.ch14
发表时间: 1995
期刊: Ciba Foundation symposium
影响因子: --
作者:
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通讯作者: Czeisler,CA
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发表时间: 1958-01-01
影响因子: 11.1
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DOI: --
发表时间: 1993
影响因子: 3.5
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DOI: --
发表时间: 1993
影响因子: 3.5
作者:
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通讯作者: C. Czeisler
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DOI: --
发表时间: 1977
影响因子: --
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