Progress in kidney transplantation: The role for systems immunology.
Progress in kidney transplantation: The role for systems immunology.
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DOI：
10.3389/fmed.2022.1070385
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发表时间：
2022
影响因子：
3.9
通讯作者：
Larsen, Christian P.
中科院分区：
文献类型：
--
作者：
Johnson, Aileen C.;Silva, Juliete A. F.;Kim, Steven C.;Larsen, Christian P.
系统生物学的发展代表着我们在进行转译研究和提供个性化和精准医学方面的能力的巨大突破。多学科方法与新技术的使用相结合，可以提取和分析大量数据，甚至可以从人体受试者获得的数量和来源有限的样本中提取和分析数据。微流控技术的不断进步、测序技术的可扩展性和可负担性以及数据分析工具的开发使多组学或系统方法的应用更容易在专门中心以外的地方使用。对实体器官移植后的同种免疫和保护性免疫反应的研究为多组学方法提供了无数的机会，然而，移植免疫学实验室才刚刚开始采用系统方法学。在这篇综述中，我们重点介绍了生物技术的进展及其如何提高我们对免疫系统及其相互作用的理解，并强调了其在移植免疫学中的潜在应用。首先，我们描述了可用的技术，重点是允许提高可伸缩性的主要进步。然后，我们回顾了移植领域的初步应用，重点放在接近临床整合的主题上。最后，我们检查了采用这些方法的主要障碍，并讨论了潜在的未来发展。
The development of systems biology represents an immense breakthrough in our ability to perform translational research and deliver personalized and precision medicine. A multidisciplinary approach in combination with use of novel techniques allows for the extraction and analysis of vast quantities of data even from the volume and source limited samples that can be obtained from human subjects. Continued advances in microfluidics, scalability and affordability of sequencing technologies, and development of data analysis tools have made the application of a multi-omics, or systems, approach more accessible for use outside of specialized centers. The study of alloimmune and protective immune responses after solid organ transplant offers innumerable opportunities for a multi-omics approach, however, transplant immunology labs are only just beginning to adopt the systems methodology. In this review, we focus on advances in biological techniques and how they are improving our understanding of the immune system and its interactions, highlighting potential applications in transplant immunology. First, we describe the techniques that are available, with emphasis on major advances that allow for increased scalability. Then, we review initial applications in the field of transplantation with a focus on topics that are nearing clinical integration. Finally, we examine major barriers to adapting these methods and discuss potential future developments.
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影响因子：
7.3
作者：
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影响因子：
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作者：
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作者：
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