Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice
Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice
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骨髓细胞中的 Bmal1 缺失可减轻高脂血症小鼠的动脉粥样硬化病变发展并抑制腹主动脉瘤形成
DOI：
10.1161/atvbaha.120.314318
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
FitzGerald Garret A.
中科院分区：
文献类型：
--
作者：
Yang Guangrui;Zhang Jiayang;Jiang Tingting;Monslow James;Tang Soon Yew;Todd Leslie;Pur Ellen;Chen Lihong;FitzGerald Garret A.
ObjectiveAlthough the molecular components of circadian rhythms oscillate in discrete cellular components of the vasculature and many aspects of vascular function display diurnal variation, the cellular connections between the molecular clock and inflammatory cardiovascular diseases remain to be elucidated. Previously we have shown that pre- versus postnatal deletion of Bmal1 (brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1), the nonredundant core clock gene has contrasting effects on atherogenesis. Here we investigated the effect of myeloid cell Bmal1 deletion on atherogenesis and abdominal aortic aneurysm formation in mice.Approach and ResultsMice lacking Bmal1 in myeloid cells were generated by crossing Bmal1 flox/flox mice with lysozyme 2 promoter-driven Cre recombinase mice on a hyperlipidemic low-density lipoprotein receptor-deficient background and were fed on a high-fat diet to induce atherosclerosis. Atherogenesis was restrained, concomitant with a reduction of aortic proinflammatory gene expression in myeloid cell Bmal1 knockout mice. Body weight, blood pressure, blood glucose, triglycerides, and cholesterol were unaltered. Similarly, myeloid cell depletion of Bmal1 also restrained Ang II (angiotensin II) induced formation of abdominal aortic aneurysm in hyperlipidemic mice. In vitro, RNA-Seq analysis demonstrated a proinflammatory response in cultured macrophages in which there was overexpression of Bmal1.ConclusionsMyeloid cell Bmal1 deletion retards atherogenesis and restrains the formation of abdominal aortic aneurysm and may represent a potential therapeutic target for inflammatory cardiovascular diseases.
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DOI：
10.1073/pnas.1703170114
发表时间：
2017-08
期刊：
Proceedings of the National Academy of Sciences
影响因子：
--
作者：
Yasuhiro Umemura;Nobuya Koike;Munehiro Ohashi;Yoshiki Tsuchiya;Q. Meng;Y. Minami;Masayuki Hara;Moe Hisatomi;K. Yagita
通讯作者：
Yasuhiro Umemura;Nobuya Koike;Munehiro Ohashi;Yoshiki Tsuchiya;Q. Meng;Y. Minami;Masayuki Hara;Moe Hisatomi;K. Yagita
影响因子：
--
作者：
U. N. Das;Allam A Rao
通讯作者：
U. N. Das;Allam A Rao
胆固醇代谢受损并增强了时钟突变小鼠的动脉粥样硬化。
影响因子：
37.8
作者：
Pan X;Jiang XC;Hussain MM
通讯作者：
Hussain MM
DOI：
10.1109/cgc.2012.90
发表时间：
2006
期刊：
2012 Second International Conference on Cloud and Green Computing
影响因子：
--
作者：
Jing-lin Jiang;P. Nilsson‐Ehle;N. Xu
通讯作者：
Jing-lin Jiang;P. Nilsson‐Ehle;N. Xu
影响因子：
2.8
作者：
Vitale, Jose;Manfredini, Roberto;Dentali, Francesco
通讯作者：
Dentali, Francesco