Cultural adaptation of Alzheimer's disease assessment scale-cognitive subscale for use in India and validation of the Tamil version for South Indian population.

Cultural adaptation of Alzheimer's disease assessment scale-cognitive subscale for use in India and validation of the Tamil version for South Indian population.
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DOI:
10.1080/13607863.2021.1875192
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发表时间:
2022-03
影响因子:
3.4
通讯作者:
Spector A
Spector A
中科院分区:
医学2区
文献类型:
--
作者:
Lakshminarayanan M;Vaitheswaran S;Srinivasan N;Nagarajan G;Ganesh A;Shaji KS;Chandra M;Krishna M;Spector A

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目前,印度语言中没有标准化的工具来评估认知的变化。我们的目标是使阿尔茨海默病评估量表-认知子量表(ADAS-Cog)适应印度的文化,并在讲泰米尔语的城市老年人中验证泰米尔语版本。两个主要利益攸关方小组和一系列定性访谈介绍了ADAS-Cog-Tamil在文化和语言方面的适应情况。在适应过程中考虑了与识字水平有关的问题。在107名参与者中完成了ADAS-Cog-Tamil的验证,其中54例确诊为轻度-中度痴呆,53例年龄、性别和教育程度匹配的对照组。同时效度用泰米尔语的Vellore痴呆筛查仪(VSID)进行检验。使用Cronbach 's alpha计算内部一致性,使用受试者工作特征下面积(AUROC)曲线值计算灵敏度和特异性数据。在子样本中建立了评分者间信度。ADAS-Cog-Tamil具有良好的内部一致性(α=0.91)、量表间信度和并发效度(与VSID-Patient版本:r=-0.84,与VSID-Caregiver版本:r=-0.79)。分值为13分,诊断痴呆的特异性为89%,敏感性为90%。ADAS-Cog-Tamil源自一个涉及服务用户和专家的严格的、可复制的语言和文化适应过程,尽管研究存在局限性,但它显示出良好的心理测量特性。它显示了在城市泰米尔语人口的临床环境中使用的潜力。该工具的英文版本源自文化适应过程,可用于整个南亚的进一步语言适应。
Currently no standardized tools are available in the Indian languages to assess changes in cognition. Our objectives are to culturally adapt the Alzheimer’s disease Assessment Scale – Cognitive Subscale (ADAS-Cog) for use in India and to validate the Tamil version in an urban Tamil-speaking older adult population. Two panels of key stakeholders and a series of qualitative interviews informed the cultural and linguistic adaptation of the ADAS-Cog-Tamil. Issues related to levels of literacy were considered during the adaptation. Validation of the ADAS-Cog-Tamil was completed with 107 participants - 54 cases with a confirmed diagnosis of mild-moderate dementia, and 53 age, gender, and education matched controls. Concurrent validity was examined with the Vellore Screening Instrument for Dementia (VSID) in Tamil. Internal consistency using Cronbach’s alpha, sensitivity, and specificity data using the Area Under the Receiver Operating Characteristics (AUROC) curve values were computed. Inter-rater reliability was established in a sub-sample. The ADAS-Cog-Tamil shows good internal consistency (α=0.91), inter-rater reliability, and concurrent validity (with VSID-Patient version: r=-0.84 and with VSID-Caregiver version: r=-0.79). A cut-off score of 13, has a specificity of 89% and sensitivity of 90% for the diagnosis of dementia. ADAS-Cog-Tamil, derived from a rigorous, replicable linguistic and cultural adaptation process involving service users and experts, shows good psychometric properties despite the limitations of the study. It shows potential for use in clinical settings with urban Tamil speaking populations. The English version of the tool derived from the cultural adaptation process could be used for further linguistic adaptation across South Asia.
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