Species comparison of acute inhalation toxicity of ozone and phosgene.
Species comparison of acute inhalation toxicity of ozone and phosgene.
复制标题
臭氧和光气急性吸入毒性的物种比较。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Judith A. Graham
中科院分区：
文献类型：
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作者：
Gary E. Hatch;R. Slade;Andrew G. Stead;Judith A. Graham
通过比较不同实验动物吸入臭氧（O3）和光气（COCl2）的浓度响应效应，更好地了解物种选择对吸入毒性研究的影响。在兔、豚鼠、大鼠、仓鼠和小鼠中测定了暴露于浓度为0.2、0.5、1.0和2.0 ppm的臭氧和暴露于浓度为0.1、0.2、0.5和1.0 ppm的COCl2 4小时的影响。以暴露后18-20 h灌洗液蛋白（LFP）积累量作为O3-和cocl2诱导肺水肿的指标。当用接近肺活量的生理盐水灌洗萎陷肺时，所有物种的LFP基础水平相似（250-350 mg/ml）。臭氧对豚鼠的影响最为明显，在0.2 ppm及以上的浓度下表现出显著的影响。小鼠、仓鼠和大鼠在1.0 ppm及以上的臭氧浓度下表现出效果，而兔子在2.0 ppm的臭氧浓度下才有反应。0.2 ppm及以上的光气同样影响小鼠、仓鼠和大鼠，而0.5 ppm及以上的光气影响豚鼠和兔子。灌洗液的回收率在不同物种之间差异很大，豚鼠在两种气体下的回收率低于其他物种。暴露于较高水平的O3而不是COCl2后，灌洗液回收率较低。本研究结果表明，物种对低浓度O3和COCl2的反应存在显著差异。这些差异似乎与体重没有简单的关系。
A comparison of the concentration-response effects of inhaled ozone (O3) and phosgene (COCl2) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation toxicity studies. The effect of 4-h exposures to ozone at concentrations of 0.2, 0.5, 1.0, and 2.0 ppm, and to COCl2 and 0.1, 0.2, 0.5, and 1.0 ppm was determined in rabbits, guinea pigs, rats, hamsters, and mice. Lavage fluid protein (LFP) accumulation 18-20 h after exposure was used as the indicator of O3- and COCl2-induced pulmonary edema. All species had similar basal levels of LFP (250-350 mg/ml) when a volume of saline that approximated the total lung capacity was used to lavage the collapsed lungs. Ozone effects were most marked in guinea pigs, which showed significant effects at 0.2 ppm and above. Mice, hamsters, and rats showed effects at 1.0 ppm O3 and above, while rabbits responded only at 2.0 ppm O3. Phosgene similarly affected mice, hamsters, and rats at 0.2 ppm and above, while guinea pigs and rabbits were affected at 0.5 ppm and above. Percent recovery of lavage fluid varied significantly between species, guinea pigs having lower recovery than other species with both gases. Lavage fluid recovery was lower following exposure to higher levels of O3 but not COCl2. Results of this study indicate that significant species differences are seen in the response to low levels of O3 and COCl2. These differences do not appear to be related in a simple manner to body weight.
评估肺水肿的单示踪技术及其在检测六亚甲基二异氰酸酯三聚体气溶胶暴露影响中的应用。
影响因子：
3.8
作者：
Valentini,JE;Wong,KL;Alarie,Y
通讯作者：
Alarie,Y