Single-tracer technique to evaluate pulmonary edema and its application to detect the effect of hexamethylene diisocyanate trimer aerosol exposures.
Single-tracer technique to evaluate pulmonary edema and its application to detect the effect of hexamethylene diisocyanate trimer aerosol exposures.
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评估肺水肿的单示踪技术及其在检测六亚甲基二异氰酸酯三聚体气溶胶暴露影响中的应用。
DOI：
10.1016/0041-008x(83)90269-7
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发表时间：
1983
影响因子：
3.8
通讯作者：
Alarie,Y
中科院分区：
文献类型：
--
作者：
Valentini,JE;Wong,KL;Alarie,Y
在暴露于2.5至39毫克/立方米的六亚甲基二异氰酸酯三聚体(HDIt)气雾剂4小时后，小鼠被静脉注射51Cr-EDTA(乙二胺四醋酸铬)。10分钟后，对肺进行了灌洗。在HDIt组小鼠的肺灌洗液中检测到更多的51Cr-EDTA，且与浓度相关。与以肺重量增加为反应的量效曲线相比，量效曲线左移。~(51)Cr-EDTA在正常小鼠的血浆浓度呈三指数曲线，而暴露于18-24 mg/m~3HDIt的小鼠的血浆浓度与此相似。然而，染毒组小鼠肺泡腔内51Cr-EDTA的含量和肺血管外腔的浓度均高于对照组。~(51)Cr-EDTA在肺内的分布符合三房室模型。根据该模型，高密度脂蛋白暴露增加了血中~(51)Cr-EDTA从血液转运到肺泡腔的渗透常数，这是高密度脂蛋白暴露小鼠肺灌洗液中51Cr-EDTA含量较高的原因。51Cr-EDTA注射加肺灌洗技术是检测肺水肿的灵敏方法。
Two hours after a four-hour exposure to hexamethylene diisocyanate trimer (HDIt) aerosol between 2.5 and 39 mg/m3, mice were injected iv with51Cr-EDTA (chromium ethylenediaminetetraacetate). Ten minutes later the lung was lavaged. A larger amount of51Cr-EDTA was detected in the lung lavage of HDIt mice than of controls in a concentration-related fashion. The concentration-response curve was shifted to the left compared with that constructed using lung weight increase as response. Kinetic studies of the plasma level of51Cr-EDTA revealed a three-exponential profile in normal mice, and similar plasma levels were obtained with mice exposed to 18–24 mg/m3HDIt. However, both the amount of51Cr-EDTA in the alveolar space and concentration in the pulmonary extravascular compartment were higher in HDIt-exposed mice than in controls. The data of51Cr-EDTA distribution in the lung were fitted with a three-compartment model. According to the model, HDIt exposures increase the permeability constants of51Cr-EDTA transport into the alveolar space from blood which accounts for the larger amount of51Cr-EDTA in the lung lavage of HDIt-exposed mice. This51Cr-EDTA injection and lung lavage technique is a sensitive method for detecting pulmonary edema.
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影响因子：
20.1
作者：
Robert Levine;R. Mellins;A. Fishman
通讯作者：
A. Fishman
从多指标数据中识别肺毛细血管通透性。
影响因子：
3.1
作者：
Thomas R. Harris;David Rowlett;Kenneth L. Brigham
通讯作者：
Kenneth L. Brigham
影响因子：
15.9
作者：
C. Goresky;R. Cronin;B. E. Wangel
通讯作者：
B. E. Wangel
肺水肿期间狗的肺组织体积。
DOI：
--
发表时间：
1978
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
B. Peterson;M. Petrini;R. Hyde;B. Schreiner
通讯作者：
B. Schreiner
一种从小型实验动物身上获取静脉血的简单方法
DOI：
--
发表时间：
1964
期刊：
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
影响因子：
--
作者：
D. Sorg;B. Buckner
通讯作者：
B. Buckner