The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
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IL-7的广泛免疫调节作用及其在疫苗中的应用
DOI：
10.3389/fimmu.2021.680442
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发表时间：
2021
影响因子：
7.3
通讯作者：
Cheng A
中科院分区：
文献类型：
--
作者：
Huang J;Long Z;Jia R;Wang M;Zhu D;Liu M;Chen S;Zhao X;Yang Q;Wu Y;Zhang S;Tian B;Mao S;Ou X;Sun D;Gao Q;Cheng A
白细胞介素-7（IL-7）由宿主组织或肿瘤中的基质细胞、角质形成细胞和上皮细胞产生，并发挥由IL-7受体（IL-7 R）介导的广泛免疫作用。IL-7主要通过JAK-STAT、PI 3 K-Akt和MAPK途径参与调节B细胞、T细胞、自然杀伤细胞和树突细胞的发育。该细胞因子参与淋巴细胞亚群的早期生成并维持所有淋巴细胞亚群的存活;特别是，IL-7对于分别协调前体B和T细胞中免疫球蛋白基因和T细胞受体基因的重排是必不可少的。此外，IL-7还能在抗病毒和抗肿瘤免疫中辅助免疫细胞的活化，在免疫功能的恢复中发挥重要作用。IL-7的这些生物学功能使其成为提高疫苗效力的重要分子佐剂，因为它可以通过延长淋巴细胞存活、增强效应细胞活性和增加抗原特异性记忆细胞产生来促进和延长针对病原体的全身免疫应答。本文综述了IL-7的生物学功能和作用机制，并总结了其对提高疫苗效力的贡献。我们希望提供一个全面的概述，这种细胞因子，并为未来的疫苗的发展提供策略。
Interleukin-7 (IL-7) is produced by stromal cells, keratinocytes, and epithelial cells in host tissues or tumors and exerts a wide range of immune effects mediated by the IL-7 receptor (IL-7R). IL-7 is primarily involved in regulating the development of B cells, T cells, natural killer cells, and dendritic cells via the JAK-STAT, PI3K-Akt, and MAPK pathways. This cytokine participates in the early generation of lymphocyte subsets and maintain the survival of all lymphocyte subsets; in particular, IL-7 is essential for orchestrating the rearrangement of immunoglobulin genes and T-cell receptor genes in precursor B and T cells, respectively. In addition, IL-7 can aid the activation of immune cells in anti-virus and anti-tumor immunity and plays important roles in the restoration of immune function. These biological functions of IL-7 make it an important molecular adjuvant to improve vaccine efficacy as it can promote and extend systemic immune responses against pathogens by prolonging lymphocyte survival, enhancing effector cell activity, and increasing antigen-specific memory cell production. This review focuses on the biological function and mechanism of IL-7 and summarizes its contribution towards improved vaccine efficacy. We hope to provide a thorough overview of this cytokine and provide strategies for the development of the future vaccines.
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影响因子：
5.5
作者：
Ahn, So-Shin;Jeon, Bo-Young;Sung, Young-Chul
通讯作者：
Sung, Young-Chul
影响因子：
6.4
作者：
Collin M;Bigley V
通讯作者：
Bigley V
影响因子：
8.7
作者：
Boller S;Grosschedl R
通讯作者：
Grosschedl R
DOI：
10.1084/jem.181.4.1399
发表时间：
1995-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bhatia SK;Tygrett LT;Grabstein KH;Waldschmidt TJ
通讯作者：
Waldschmidt TJ
影响因子：
6.4
作者：
Chetoui, Nizar;Boisvert, Marc;Aoudjit, Fawzi
通讯作者：
Aoudjit, Fawzi