Auditory orienting and inhibition of return in schizophrenia: a functional magnetic resonance imaging study.
Auditory orienting and inhibition of return in schizophrenia: a functional magnetic resonance imaging study.
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DOI：
10.1016/j.pnpbp.2011.12.011
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发表时间：
2012-04-27
影响因子：
5.6
通讯作者：
Mayer, Andrew R.
中科院分区：
文献类型：
--
作者：
Abbott, Christopher C.;Merideth, Flannery;Ruhl, David;Yang, Zhen;Clark, Vincent P.;Calhoun, Vince D.;Hanlon, Faith M.;Mayer, Andrew R.
精神分裂症（SP）患者在视觉任务中表现出注意重定向和返回抑制（IOR）缺陷。然而，目前尚不清楚这些缺陷是否是超模态的性质，以及这些缺陷如何与其他领域的认知功能障碍。此外，这种病理性定向反应的神经元相关性尚未在视觉或听觉模式中进行研究。因此，30 SP和30名健康对照（HC）进行了评估，广泛的临床协议和功能性磁共振成像（fMRI）在听觉线索范式。SP表现出增加的成本和延迟IOR在听觉定向，这表明注意力脱离线索位置的时间间隔延长。此外，IOR发展的延迟与注意力/抑制和工作记忆领域的正式神经心理学测试的认知缺陷相关。事件相关功能磁共振成像显示了额顶网络的特征性激活（无效试验>有效试验），但在注意力重定向或IOR期间，患者和HC之间的功能激活没有差异。目前的研究结果表明，定向缺陷是超模态的性质在SP，并与高阶认知缺陷，直接干扰日常功能。
Patients with schizophrenia (SP) exhibit deficits in both attentional reorienting and inhibition of return (IOR) during visual tasks. However, it is currently unknown whether these deficits are supramodal in nature and how these deficits relate to other domains of cognitive dysfunction. In addition, the neuronal correlates of this pathological orienting response have not been investigated in either the visual or auditory modality. Therefore, thirty SP and 30 healthy controls (HC) were evaluated with an extensive clinical protocol and functional magnetic resonance imaging (fMRI) during an auditory cuing paradigm. SP exhibited both increased costs and delayed IOR during auditory orienting, suggesting a prolonged interval for attentional disengagement from cued locations. Moreover, a delay in the development of IOR was associated with cognitive deficits on formal neuropsychological testing in the domains of attention/inhibition and working memory. Event-related fMRI showed the characteristic activation of a frontoparietal network (invalid trials > valid trials), but there were no differences in functional activation between patients and HC during either attentional reorienting or IOR. Current results suggest that orienting deficits are supramodal in nature in SP, and are related to higher-order cognitive deficits that directly interfere with day-to-day functioning.
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影响因子：
5.7
作者：
Ford, JM;Johnson, MB;Mathalon, DH
通讯作者：
Mathalon, DH
DOI：
10.1080/13803390903146949
发表时间：
2010-01-01
影响因子：
2.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
Light, GA
影响因子：
10.5
作者：
ADDINGTON, D;ADDINGTON, J;MATICKATYNDALE, E
通讯作者：
MATICKATYNDALE, E