TRPC channels in smooth muscle cells.

TRPC channels in smooth muscle cells.
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DOI:
10.2741/3660
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发表时间:
2010-06-01
期刊:
Frontiers in bioscience (Landmark edition)
影响因子:
--
通讯作者:
Trebak M
Trebak M
中科院分区:
其他
文献类型:
--
作者:
Gonzalez-Cobos JC;Trebak M

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在更广泛的Trp超家族中,瞬时受体电位规范(TRPC)蛋白构成了一个由7个(TRPC1-7)非选择性阳离子通道组成的家族。TRPC1、TRPC3、TRPC4、TRPC5和TRPC6通道表达于各种血管的血管平滑肌细胞以及子宫和胃肠道等器官的平滑肌细胞。最近,TRPC通道已成为控制平滑肌功能的重要角色。本文将对TRPC通道对血管系统的生理和病理生理反应的研究进行回顾分析。
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.
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