TRPC channels in smooth muscle cells.
TRPC channels in smooth muscle cells.
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DOI:
10.2741/3660
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发表时间:
2010-06-01
期刊:
影响因子:
--
通讯作者:
Trebak M
中科院分区:
文献类型:
--
作者:
Gonzalez-Cobos JC;Trebak M
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.
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