Sensing and Signaling of Methionine Metabolism.
Sensing and Signaling of Methionine Metabolism.
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DOI：
10.3390/metabo11020083
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发表时间：
2021-01-31
期刊：
影响因子：
4.1
通讯作者：
Kaiser P
中科院分区：
文献类型：
--
作者：
Lauinger L;Kaiser P
氨基酸蛋氨酸的可利用性对单个细胞和整个生物体的生理有显著影响。例如，大多数癌细胞，但不是正常细胞，高度依赖与蛋氨酸相关的代谢途径的高通量，而限制蛋氨酸的饮食延长了模式生物的健康寿命。蛋氨酸对生理学的影响超越了它在蛋白质中启动翻译和结合的作用。它的许多代谢产物对细胞功能有重要影响，包括表观遗传调节、维持氧化还原平衡、多胺合成和磷脂稳态。作为这些重要途径的中心组成部分，细胞需要感知蛋氨酸可获得性的机制。当蛋氨酸水平较低时，细胞反应程序诱导转录和信号状态，以重塑代谢程序并维持蛋氨酸代谢。此外，在蛋氨酸饥饿条件下，诱导了进化保守的细胞周期停滞，以确保细胞和基因组的完整性。蛋氨酸及其代谢产物对所有生物的细胞生长、增殖和发育都是至关重要的。然而，甲硫氨酸的感知机制是多样的。在这里，我们回顾了目前关于酵母和哺乳动物细胞中蛋氨酸感知机制的知识，并将讨论蛋氨酸失衡对癌症和衰老的影响。
Availability of the amino acid methionine shows remarkable effects on the physiology of individual cells and whole organisms. For example, most cancer cells, but not normal cells, are hyper dependent on high flux through metabolic pathways connected to methionine, and diets restricted for methionine increase healthy lifespan in model organisms. Methionine’s impact on physiology goes beyond its role in initiation of translation and incorporation in proteins. Many of its metabolites have a major influence on cellular functions including epigenetic regulation, maintenance of redox balance, polyamine synthesis, and phospholipid homeostasis. As a central component of such essential pathways, cells require mechanisms to sense methionine availability. When methionine levels are low, cellular response programs induce transcriptional and signaling states to remodel metabolic programs and maintain methionine metabolism. In addition, an evolutionary conserved cell cycle arrest is induced to ensure cellular and genomic integrity during methionine starvation conditions. Methionine and its metabolites are critical for cell growth, proliferation, and development in all organisms. However, mechanisms of methionine perception are diverse. Here we review current knowledge about mechanisms of methionine sensing in yeast and mammalian cells, and will discuss the impact of methionine imbalance on cancer and aging.
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全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
3.2
作者：
CHEREST, H;THOMAS, D;SURDINKERJAN, Y
通讯作者：
SURDINKERJAN, Y
影响因子：
4.3
作者：
Booher, Keith;Lin, Da-Wei;Kaiser, Peter
通讯作者：
Kaiser, Peter
DOI：
10.1073/pnas.71.4.1133
发表时间：
1974-01-01
影响因子：
11.1
作者：
HALPERN, BC;CLARK, BR;SMITH, RA
通讯作者：
SMITH, RA
影响因子：
4.5
作者：
Hansen M;Hsu AL;Dillin A;Kenyon C
通讯作者：
Kenyon C