Default mode network connectivity encodes clinical pain: an arterial spin labeling study.
Default mode network connectivity encodes clinical pain: an arterial spin labeling study.
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DOI：
10.1016/j.pain.2012.07.029
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发表时间：
2013-01
期刊：
影响因子：
7.4
通讯作者：
Napadow V
中科院分区：
文献类型：
--
作者：
Loggia ML;Kim J;Gollub RL;Vangel MG;Kirsch I;Kong J;Wasan AD;Napadow V
神经成像研究表明，慢性疼痛患者的大脑解剖功能特性发生了变化。然而，对支持临床疼痛感知的大脑回路的研究面临着巨大的挑战，特别是在使用传统的神经成像方法时。虽然临床疼痛的潜在神经成像标记物包括静息脑连接，但这些横断面研究并未检查受试者内疼痛加剧的敏感性。我们使用双重回归概率独立分量分析方法来研究动脉自旋标记(ASL)数据的静息状态连通性。比较了慢性下腰痛(CLBP)患者和健康对照组在实施旨在加剧患者临床疼痛程度的动作前后的脑连接性。我们的分析确定了多个静止状态网络，包括默认模式网络(DMN)。在基线时，患者表现出更强的DMN与前扣带回前皮质(PgACC)、左侧顶下小叶和右侧脑岛(RINs)的连接。患者的基线临床疼痛与DMN与右侧脑岛的连接强度(DMN-RINs)呈正相关。经过校准的物理动作的表现会引起疼痛的变化，这与DMN-RINs连接的变化是平行的。动作也扰乱了DMN-pgACC的连接，在基线时，这与疼痛呈反相关。最后，基线DMN连接性预测了动作引起的疼痛和DMN-RINs连接性的变化。我们的结果支持使用ASL来评估临床疼痛，以及使用静息DMN连接作为潜在的神经成像生物标记物来评估慢性疼痛。
Neuroimaging studies have suggested the presence of alterations in the anatomo-functional properties of the brain of patients with chronic pain. However, investigation of the brain circuitry supporting the perception of clinical pain presents significant challenges, particularly when using traditional neuroimaging approaches. While potential neuroimaging markers for clinical pain have included resting brain connectivity, these cross-sectional studies have not examined sensitivity to within-subject exacerbation of pain. We used the dual regression probabilistic Independent Component Analysis approach to investigate resting-state connectivity on Arterial Spin Labeling (ASL) data. Brain connectivity was compared between patients with chronic low back pain (cLBP) and healthy controls, before and after the performance of maneuvers aimed at exacerbating clinical pain levels in the patients. Our analyses identified multiple resting state networks, including the Default Mode Network (DMN). At baseline, patients demonstrated stronger DMN connectivity to the pregenual anterior cingulate cortex (pgACC), left inferior parietal lobule and right insula (rINS). Patients’ baseline clinical pain correlated positively with connectivity strength between the DMN and right insula (DMN-rINS). The performance of calibrated physical maneuvers induced changes in pain, which were paralleled by changes in DMN-rINS connectivity. Maneuvers also disrupted the DMN-pgACC connectivity, which at baseline was anti-correlated with pain. Finally, baseline DMN connectivity predicted maneuver-induced changes in both pain and DMN-rINS connectivity. Our results support the use of ASL to evaluate clinical pain, and the use of resting DMN connectivity as a potential neuroimaging biomarker for chronic pain perception.
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DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.3
作者：
Baliki, Marwan N.;Chialvo, Dante R.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
7.4
作者：
Bingel, U;Lorenz, J;Büchel, C
通讯作者：
Büchel, C
影响因子：
7.4
作者：
GRACELY, RH;MCGRATH, P;DUBNER, R
通讯作者：
DUBNER, R