The Role of Non-Coding RNAs as Prognostic Factor, Predictor of Drug Response or Resistance and Pharmacological Targets, in the Cutaneous Squamous Cell Carcinoma.
The Role of Non-Coding RNAs as Prognostic Factor, Predictor of Drug Response or Resistance and Pharmacological Targets, in the Cutaneous Squamous Cell Carcinoma.
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非编码 RNA 作为皮肤鳞状细胞癌预后因素、药物反应或耐药性预测因子以及药理学靶标的作用。
DOI：
10.3390/cancers12092552
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发表时间：
2020-09-08
期刊：
影响因子：
5.2
通讯作者：
Azzariti A
中科院分区：
文献类型：
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作者：
Garofoli M;Volpicella M;Guida M;Porcelli L;Azzariti A
皮肤鳞状细胞癌在分子水平上知之甚少，然而，新出现的证据强调了非编码RNA在肿瘤发生和肿瘤进展中起着关键作用。在此，我们关注非编码RNA的翻译潜力，如miRNA，环状RNA和lncRNA，通过报告尖端发现，表明它们可以被认为是对不同类别药物（包括化疗药物和免疫检查点抑制剂）的反应的潜在预测因子，并作为可靠的预测因子。此外，通过报道涉及非编码RNA的药物敏感性和耐药性的分子机制，我们强调了它们作为可药物靶点的潜在作用，并为CSCC患者提出了新的治疗选择。皮肤鳞状细胞癌（CSCC）是高加索人群中最常见的角化细胞来源的皮肤癌。暴露于紫外线辐射（UVRs）代表致癌的主要风险，导致表皮角质形成细胞中DNA损伤的大量积累，伴随不受控制的过度增殖和肿瘤发展。CSCC对当前治疗选择的有限且很少持久的反应促使研究人员寻找新的治疗策略。近年来，多组学方法已用于鉴定和预测非编码RNA（ncRNA），如microRNA（miRNAs）、circularRNA（circRNA）和长链非编码RNA（lncRNA）在不同肿瘤类型（包括CSCC）中调控多种细胞过程的关键作用。ncRNA可以通过彼此相互作用或与DNA和蛋白质（如转录因子和RNA结合蛋白）相互作用来调节转录和转录后事件。本文就ncRNA在肿瘤发生中的作用及其作为诊断生物标志物和治疗靶点的潜在作用作一综述。
Cutaneous Squamous Cell Carcinoma is poorly understood at a molecular level, however emerging evidence have highlighted that non-coding RNAs play a key role in the oncogenesis and tumor progression. Herein we focused on the translational potential of non-coding RNAs, such as miRNAs, circular RNAs and lncRNAs, by reporting cutting edge findings showing that they can be considered as potential predictors of response to diverse class of drugs, including chemotherapeutics and immune checkpoints inhibitors and as reliable prognosticators. Additionally, by reporting the molecular mechanisms of drug sensitivity and resistance in which non-coding RNAs are involved, we highlighted their potential role as druggable targets and suggested new therapeutic options for CSCC patients. Cutaneous squamous cell carcinoma (CSCC) is the most common keratinocyte-derived skin cancer in the Caucasian population. Exposure to UV radiations (UVRs) represents the main risk carcinogenesis, causing a considerable accumulation of DNA damage in epidermal keratinocytes with an uncontrolled hyperproliferation and tumor development. The limited and rarely durable response of CSCC to the current therapeutic options has led researchers to look for new therapeutic strategies. Recently, the multi-omics approaches have contributed to the identification and prediction of the key role of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), circularRNAs (circRNAs) and long non-coding RNAs (lncRNAs) in the regulation of several cellular processes in different tumor types, including CSCC. ncRNAs can modulate transcriptional and post-transcriptional events by interacting either with each other or with DNA and proteins, such as transcription factors and RNA-binding proteins. In this review, the implication of ncRNAs in tumorigenesis and their potential role as diagnostic biomarkers and therapeutic targets in human CSCC are reported.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
3.7
作者：
Bai, Lin;Wang, Aihua;Zhang, Xiao
通讯作者：
Zhang, Xiao
DOI：
10.1111/bjd.15236
发表时间：
2017-07
期刊：
The British journal of dermatology
影响因子：
--
作者：
Cañueto J;Cardeñoso-Álvarez E;García-Hernández JL;Galindo-Villardón P;Vicente-Galindo P;Vicente-Villardón JL;Alonso-López D;De Las Rivas J;Valero J;Moyano-Sanz E;Fernández-López E;Mao JH;Castellanos-Martín A;Román-Curto C;Pérez-Losada J
通讯作者：
Pérez-Losada J
影响因子：
7.5
作者：
Chen, Dan;Yan, Wangxiang;Chen, Yu
通讯作者：
Chen, Yu
影响因子：
82.9
作者：
通讯作者：
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