Strategies for optimizing water-exchange rates of lanthanide-based contrast agents for magnetic resonance imaging.
Strategies for optimizing water-exchange rates of lanthanide-based contrast agents for magnetic resonance imaging.
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DOI：
10.3390/molecules18089352
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发表时间：
2013-08-05
期刊：
影响因子：
--
通讯作者：
Allen MJ
中科院分区：
文献类型：
--
作者：
Siriwardena-Mahanama BN;Allen MJ
这篇综述描述了磁共振成像 (MRI) 造影剂水交换率调整策略的最新进展。水交换率在确定造影剂的效率方面起着至关重要的作用；因此，为了实现高效率，必须优化水交换率等参数。这种需求导致了广泛的研究工作，通过化学改变充当造影剂的金属络合物的配位环境来调节水交换率。本综述的重点是基于配位化学的策略，用于调整 MRI 中基于镧系元素 (III) 的造影剂的水交换率。重点将放在 21 世纪发表的结果，以及这些策略对造影剂设计的影响。
This review describes recent advances in strategies for tuning the water-exchange rates of contrast agents for magnetic resonance imaging (MRI). Water-exchange rates play a critical role in determining the efficiency of contrast agents; consequently, optimization of water-exchange rates, among other parameters, is necessary to achieve high efficiencies. This need has resulted in extensive research efforts to modulate water-exchange rates by chemically altering the coordination environments of the metal complexes that function as contrast agents. The focus of this review is coordination-chemistry-based strategies used to tune the water-exchange rates of lanthanide(III)-based contrast agents for MRI. Emphasis will be given to results published in the 21st century, as well as implications of these strategies on the design of contrast agents.
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