Prostaglandin D2 synthase/prostaglandin D2/TWIST2 signaling inhibits breast cancer proliferation
Prostaglandin D2 synthase/prostaglandin D2/TWIST2 signaling inhibits breast cancer proliferation
复制标题
前列腺素 D2 合酶/前列腺素 D2/TWIST2 信号传导抑制乳腺癌增殖
DOI：
10.1097/cad.0000000000001111
复制
发表时间：
2021-07
影响因子：
2.3
通讯作者：
Huang Jian
中科院分区：
文献类型：
--
作者：
Pan Jun;Zhang Leyi;Huang Jian
补充数字内容可在文本中找到。尽管过去几年在所有乳腺癌亚型的靶向和免疫治疗方面取得了令人兴奋的成就，但乳腺癌死亡率的下降已经放缓，迫切需要进一步扩大高质量治疗的选择。前列腺素D2合酶（PTGDS）/前列腺素D2（PGD 2）在多种肿瘤中发挥重要作用，并具有组织特异性，但在乳腺癌中的相关报道较少。因此，本研究的目的是研究PTGDS/PGD 2在乳腺癌中的作用，通过大规模的生物信息学分析和在人乳腺癌细胞系上进行的体外实验。我们的研究结果表明，PTGDS表达水平高的患者显示出肿瘤增殖的潜力降低。PGD 2处理显著抑制乳腺癌细胞的增殖和迁移，这是由TWIST 2表达减少介导的。TWIST 2过表达可逆转PGD 2对乳腺癌细胞增殖的抑制作用。这些结果提供了新的证据，PTGDS可能在调节乳腺癌生长中发挥重要作用，并暗示其在治疗乳腺癌中的潜在用途。
Supplemental Digital Content is available in the text. Though the past few years have witnessed exciting achievements in targeted and immunotherapeutic treatments of all breast cancer subtypes, yet the decline in breast cancer mortality has been slowed, urging the need for further expanding options of high-quality treatments. Prostaglandin D2 synthase (PTGDS)/prostaglandin D2 (PGD2) play important roles in a variety of cancer types and show tissue-specificity, however, there are limited relevant reports in breast cancer. Therefore, the aims of the present study were to investigate the effects of PTGDS/PGD2 in breast cancer by large-scale bioinformatic analysis and in vitro experiments conducted on human breast cancer cell lines. Results of our study indicated that patients with high levels of PTGDS expression showed a reduced potential of tumor proliferation. PGD2 treatment significantly inhibited the proliferation and migration of breast cancer cells, which was mediated by the reduced expression of TWIST2. Overexpression of TWIST2 reversed the inhibitory effects of PGD2 on breast cancer cell proliferation. These results provided the novel evidence that PTGDS may play a significant role in modulating breast cancer growth, with implications for its potential use in treating breast cancer.
登录
查看更多内容
DOI：
10.1016/j.bbamcr.2012.08.013
发表时间：
2012-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Chang-Chieh Wu;R. Shyu;Chun-Hua Wang;T. Tsai;Lu-Kai Wang;Mao-Liang Chen;Shun-yuan Jiang;F. Tsai
通讯作者：
Chang-Chieh Wu;R. Shyu;Chun-Hua Wang;T. Tsai;Lu-Kai Wang;Mao-Liang Chen;Shun-yuan Jiang;F. Tsai
DOI：
10.1097/pai.0000000000000717
发表时间：
2020-02-01
影响因子：
1.6
作者：
Kim, Ga-Eon;Kim, Nah Ihm;Kang, Keunsoo
通讯作者：
Kang, Keunsoo
PGD2/PTGDR2 信号传导限制胃癌的自我更新和肿瘤发生
影响因子：
5.2
作者：
Zhang Bin;Bie Qingli;Wu Peipei;Zhang Jie;You Benshuai;Shi Hui;Qian Hui;Xu Wenrong
通讯作者：
Xu Wenrong
Twist2通过促进上皮-间质转化和癌症干细胞样细胞自我更新促进乳腺癌进展
影响因子：
8
作者：
Fang, X.;Cai, Y.;Ouyang, G.
通讯作者：
Ouyang, G.
DOI：
10.1186/s13046-018-0975-0
发表时间：
2018-12-12
影响因子：
11.3
作者：
Ciccone, Valerio;Terzuoli, Erika;Ziche, Marina
通讯作者：
Ziche, Marina