Sexual experience enhances cognitive flexibility and dendritic spine density in the medial prefrontal cortex.
Sexual experience enhances cognitive flexibility and dendritic spine density in the medial prefrontal cortex.
复制标题
性体验增强了内侧前额叶皮层的认知灵活性和树突棘密度。
DOI：
10.1016/j.nlm.2015.07.007
复制
发表时间：
2015
影响因子：
2.7
通讯作者：
Gould,Elizabeth
中科院分区：
文献类型：
--
作者：
Glasper,EricaR;LaMarca,ElizabethA;Bocarsly,MiriamE;Fasolino,Maria;Opendak,Maya;Gould,Elizabeth
内侧前额叶皮质对认知灵活性很重要，认知灵活性是一种受环境条件和特定经验影响的能力。众所周知，慢性束缚应激等厌恶经历会损害大鼠在认知灵活性任务中的表现，特别是注意力定势转移。伴随着这种表现的下降，慢性应激减少了内侧前额叶皮质锥体神经元上的树突棘的数量。以前没有研究检验过一种有益的经历，即交配，是否会影响雄性大鼠内侧前额叶皮质的认知灵活性和树突。为了测试这种可能性，我们让成年雄性大鼠每天接触一次接受性行为的雌性大鼠，持续一周，评估注意力定势转移的表现，然后分析它们的大脑树突棘的变化。我们发现，性体验改善了在外向定势转移上的表现，众所周知，这需要内侧前额叶皮质。此外，我们观察到性行为后，内侧前额叶皮质锥体神经元顶端和基端树突上的树突密度增加，但眼眶前额叶皮质没有。我们还发现，性经历增加了齿状回颗粒神经元上的树突密度。腹侧海马向内侧前额叶皮质发出直接投射，增加了内侧前额叶皮质结构和功能改变所必需的海马体经验依赖性改变的可能性。作为研究这一点的第一次尝试，我们在每一次日常的性体验之后，用GABA激动剂Muscimol使腹侧海马区失活，以观察对认知灵活性的有益影响是否被消除。与我们的假设相反，在性行为经历后阻止海马体活动对增强认知灵活性没有影响。综上所述，这些发现表明，性体验提高了内侧前额叶皮质树突棘的密度和认知灵活性，但这些影响可能不需要海马体的持续输入。
The medial prefrontal cortex is important for cognitive flexibility, a capability that is affected by environmental conditions and specific experiences. Aversive experience, such as chronic restraint stress, is known to impair performance on a task of cognitive flexibility, specifically attentional set-shifting, in rats. Concomitant with this performance decrement, chronic stress reduces the number of dendritic spines on pyramidal neurons in the medial prefrontal cortex. No previous studies have examined whether a rewarding experience, namely mating, affects cognitive flexibility and dendritic spines in the medial prefrontal cortex of male rats. To test this possibility, we exposed adult male rats to sexual receptive females once daily for one week, assessed attentional set-shifting performance, and then analyzed their brains for changes in dendritic spines. We found that sexual experience improved performance on extradimensional set-shifting, which is known to require the medial prefrontal cortex. Additionally, we observed increased dendritic spine density on apical and basal dendrites of pyramidal neurons in the medial prefrontal cortex, but not the orbitofrontal cortex, after sexual experience. We also found that sexual experience enhanced dendritic spine density on granule neurons of the dentate gyrus. The ventral hippocampus sends a direct projection to the medial prefrontal cortex, raising the possibility that experience-dependent changes in the hippocampus are necessary for alterations in medial prefrontal cortex structure and function. As a first attempt at investigating this, we inactivated the ventral hippocampus with the GABA agonist muscimol, after each daily bout of sexual experience to observe whether the beneficial effects on cognitive flexibility were abolished. Contrary to our hypothesis, blocking hippocampal activity after sexual experience had no impact on enhanced cognitive flexibility. Taken together, these findings indicate that sexual experience enhances medial prefrontal cortex dendritic spine density and cognitive flexibility but that these effects may not require continual input from the hippocampus.
登录
查看更多内容
用于研究抗原特异性鼠 T 细胞增殖的简单可靠的系统。
影响因子：
2.2
作者：
K. C. Lee;B. Singh;M. Barton;A. Procyshyn;Michael E. Wong
通讯作者：
Michael E. Wong
影响因子：
4.4
作者：
A. Bhattacharya;M. Dorf;T. Springer
通讯作者：
A. Bhattacharya;M. Dorf;T. Springer
O,O,S-硫代磷酸三甲酯对免疫能力的影响
DOI：
--
发表时间：
1985
期刊：
影响因子：
--
作者：
B. Devens;M. Grayson;T. Imamura;K. Rodgers
通讯作者：
K. Rodgers
PMA 和 IL 1 独立且协同的胸腺细胞增殖活性。
影响因子：
4.4
作者：
T. Krakauer;D. Mizel;J. Oppenheim
通讯作者：
J. Oppenheim
巨噬细胞的功能异质性：具有不同抗原结合活性和免疫复合物受体的腹膜巨噬细胞亚类。
影响因子：
6.4
作者：
W. Walker
通讯作者：
W. Walker