Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.
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DOI：
10.1016/j.bbadis.2013.05.017
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发表时间：
2014-03
影响因子：
6.2
通讯作者：
Lee, Jongsoon
中科院分区：
文献类型：
--
作者：
Lee, Byung-Cheol;Lee, Jongsoon
越来越多的证据表明炎症是肥胖引起的胰岛素抵抗发展的重要致病介质。现在人们普遍认为，组织驻留免疫细胞在调节这种肥胖引起的炎症中发挥着重要作用。脂肪组织 (AT) 驻留免疫细胞所发挥的作用已得到特别广泛的研究。 AT 包含大多数类型的免疫细胞，肥胖会增加其数量和激活水平，特别是在 AT 巨噬细胞 (ATM) 中。 AT 中发现的其他促炎细胞包括中性粒细胞、Th1 CD4 T 细胞、CD8 T 细胞、B 细胞、DC 和肥大细胞。然而，AT 还含有抗炎细胞，可以对抗促炎免疫细胞，而促炎免疫细胞是肥胖引起的组织炎症的原因。这些抗炎细胞包括调节性 CD4 T 细胞 (Treg)、Th2 CD4 T 细胞和嗜酸性粒细胞。因此，AT 炎症是由促炎和抗炎免疫细胞稳态的调节形成的，而肥胖使这种平衡偏向更促炎的状态。最近的遗传学研究揭示了几种参与肥胖引起的炎症和胰岛素抵抗发展的分子。在这篇综述中，讨论了参与调节肥胖引起的炎症和胰岛素抵抗的细胞和分子参与者，特别关注细胞参与者在这些发病机制中的作用。
There is increasing evidence showing that inflammation is an important pathogenic mediator of the development of obesity-induced insulin resistance. It is now generally accepted that tissue-resident immune cells play a major role in the regulation of this obesity-induced inflammation. The roles that adipose tissue (AT)-resident immune cells play have been particularly extensively studied. AT contains most types of immune cells and obesity increases their numbers and activation levels, particularly in AT macrophages (ATMs). Other pro-inflammatory cells found in AT include neutrophils, Th1 CD4 T cells, CD8 T cells, B cells, DCs, and mast cells. However, AT also contains anti-inflammatory cells that counter the pro-inflammatory immune cells that are responsible for the obesity-induced inflammation in this tissue. These anti-inflammatory cells include regulatory CD4 T cells (Tregs), Th2 CD4 T cells, and eosinophils. Hence, AT inflammation is shaped by the regulation of pro- and anti-inflammatory immune cell homeostasis, and obesity skews this balance towards a more pro-inflammatory status. Recent genetic studies revealed several molecules that participate in the development of obesity-induced inflammation and insulin resistance. In this review, the cellular and molecular players that participate in the regulation of obesity-induced inflammation and insulin resistance are discussed, with particular attention being placed on the roles of the cellular players in these pathogeneses.
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影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
7.7
作者：
Duncan, BB;Schmidt, MI;Heiss, G
通讯作者：
Heiss, G
影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.9
作者：
Chang, Y-H;Ho, K-T;Shiau, M-Y
通讯作者：
Shiau, M-Y