Mast cell-orchestrated immunity to pathogens.
Mast cell-orchestrated immunity to pathogens.
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DOI：
10.1038/nri2782
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发表时间：
2010-06
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影响因子：
--
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中科院分区：
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--
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虽然肥大细胞在世纪前就被发现了，但直到最近，它们在过敏反应中的作用之外的功能仍然难以捉摸。然而，越来越多的人认识到这些细胞的重要生理功能是识别病原体和调节适当的免疫反应。由于肥大细胞能够从细胞内储存中立即释放几种促炎介质，并且它们位于宿主-环境界面，因此已显示肥大细胞对于感染期间的最佳免疫应答至关重要。肥大细胞似乎通过在检测到病原体后改变炎症环境以及通过将各种免疫细胞动员到感染部位和引流淋巴结来发挥这些作用。有趣的是，这些反应的特征和时间可以根据病原体刺激的类型、病原体识别的位置和响应肥大细胞的致敏状态而变化。最近使用肥大细胞激活剂作为有效疫苗佐剂的研究显示了利用这些细胞赋予针对微生物病原体的保护性免疫的潜力。
Although mast cells were discovered more than a century ago, their functions beyond their role in allergic responses remained elusive until recently. However, there is a growing appreciation that an important physiological function of these cells is the recognition of pathogens and modulation of appropriate immune responses. Because of their ability to instantly release several pro-inflammatory mediators from intracellular stores and their location at the host–environment interface, mast cells have been shown to be crucial for optimal immune responses during infection. Mast cells seem to exert these effects by altering the inflammatory environment after detection of a pathogen and by mobilizing various immune cells to the site of infection and to draining lymph nodes. Interestingly, the character and timing of these responses can vary depending on the type of pathogen stimulus, location of pathogen recognition and sensitization state of the responding mast cells. Recent studies using mast cell activators as effective vaccine adjuvants show the potential of harnessing these cells to confer protective immunity against microbial pathogens.
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影响因子：
64.8
作者：
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