Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.
Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.
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含有单加氧酶3（FMO3）基因的黄素的多态性不容易发生高加索人的高血压。
DOI：
10.1186/1471-2350-6-41
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发表时间：
2005-12-02
影响因子：
--
通讯作者：
Treacy, EP
中科院分区：
文献类型：
--
作者：
Dolan, C;Shields, DC;Stanton, A;O'Brien, E;Lambert, DM;O'Brien, JK;Treacy, EP
隐性疾病三甲胺尿是由FMO3基因缺陷引起的，可能与高血压有关。我们研究了FMO3基因的常见多态性是否会增加血压升高和/或原发性高血压的风险。FMO3基因型（E158K, V257M, E308G）在387例动态收缩压和舒张压健康受试者和1649例心血管疾病人群中进行了检测，其中691例（41.9%）有高血压病史，需要药物治疗。测定单倍型并记录其分布。在健康人群中，4种常见单倍型与日间收缩压之间没有统计学上的显著关联（p = 0.65）。4种常见单倍型与心血管疾病患者高血压状态之间均无统计学意义（p = 0.80）。这些结果表明，FMO3基因的变异不会使该人群易患原发性高血压。
The recessive disorder trimethylaminuria is caused by defects in the FMO3 gene, and may be associated with hypertension. We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension. FMO3 genotypes (E158K, V257M, E308G) were determined in 387 healthy subjects with ambulatory systolic and diastolic blood pressure measurements, and in a cardiovascular disease population of 1649 individuals, 691(41.9%) of whom had a history of hypertension requiring drug treatment. Haplotypes were determined and their distribution noted. There was no statistically significant association found between any of the 4 common haplotypes and daytime systolic blood pressure in the healthy population (p = 0.65). Neither was a statistically significant association found between the 4 common haplotypes and hypertension status among the cardiovascular disease patients (p = 0.80). These results suggest that the variants in the FMO3 gene do not predispose to essential hypertension in this population.
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影响因子：
4.1
作者：
Cashman, JR;Bi, YA;Treacy, E
通讯作者：
Treacy, E
影响因子：
12.3
作者：
Hamet, P
通讯作者：
Hamet, P
影响因子：
168.9
作者：
KAPLAN, NM
通讯作者：
KAPLAN, NM
影响因子：
5.1
作者：
ELFARRA, AA
通讯作者：
ELFARRA, AA
影响因子：
8.3
作者：
BURT, VL;WHELTON, P;LABARTHE, D
通讯作者：
LABARTHE, D