Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism.
Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism.
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母胎界面免疫细胞的代谢重编程和免疫代谢技术的发展
DOI：
10.3389/fimmu.2021.717014
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发表时间：
2021
影响因子：
7.3
通讯作者：
Diao L
中科院分区：
文献类型：
--
作者：
Wei Y;Ding J;Li J;Cai S;Liu S;Hong L;Yin T;Zhang Y;Diao L
免疫与代谢相互依存、相互协调，是机体维持内环境稳定的核心机制。在肿瘤免疫学研究中，免疫代谢一直是一个研究热点，近年来取得了突破性的进展。然而，在母胎医学领域，免疫代谢的研究仍然滞后。直接研究免疫代谢在子宫内膜微环境中的作用和母胎免疫耐受的调节的报告相对较少。本文重点介绍了免疫代谢的主要研究技术及其发展、母胎界面的免疫细胞及其功能实现所需的代谢特征，并在缺乏证据和线索的基础上探讨了免疫代谢与妊娠调控的相互作用，试图提出一些新的研究方向和视角。
Immunity and metabolism are interdependent and coordinated, which are the core mechanisms for the body to maintain homeostasis. In tumor immunology research, immunometabolism has been a research hotspot and has achieved groundbreaking changes in recent years. However, in the field of maternal-fetal medicine, research on immunometabolism is still lagging. Reports directly investigating the roles of immunometabolism in the endometrial microenvironment and regulation of maternal-fetal immune tolerance are relatively few. This review highlights the leading techniques used to study immunometabolism and their development, the immune cells at the maternal-fetal interface and their metabolic features required for the implementation of their functions, explores the interaction between immunometabolism and pregnancy regulation based on little evidence and clues, and attempts to propose some new research directions and perspectives.
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影响因子：
82.9
作者：
Cha J;Sun X;Dey SK
通讯作者：
Dey SK
影响因子：
11.4
作者：
Calton EK;Keane KN;Raizel R;Rowlands J;Soares MJ;Newsholme P
通讯作者：
Newsholme P
DOI：
10.1016/j.tem.2015.09.012
发表时间：
2015-12
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Castello A;Hentze MW;Preiss T
通讯作者：
Preiss T
影响因子：
7.4
作者：
Amantonico, Andrea;Urban, Pawel L.;Zenobi, Renato
通讯作者：
Zenobi, Renato
影响因子：
64.5
作者：
Dang EV;Barbi J;Yang HY;Jinasena D;Yu H;Zheng Y;Bordman Z;Fu J;Kim Y;Yen HR;Luo W;Zeller K;Shimoda L;Topalian SL;Semenza GL;Dang CV;Pardoll DM;Pan F
通讯作者：
Pan F