Krüppel-like transcription factors and control of pluripotency.

Krüppel-like transcription factors and control of pluripotency.
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DOI:
10.1186/1741-7007-8-125
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发表时间:
2010-09-27
期刊:
影响因子:
5.4
通讯作者:
Savatier P
Savatier P
中科院分区:
生物学2区
文献类型:
--
作者:
Bourillot PY;Savatier P

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最近的论文已经证明了Krüppel样转录因子2、4和5在控制小鼠胚胎干细胞多能性中的作用。然而,尚不清楚每个因素是否具有独特的作用,或者它们是否在功能上是多余的。Parisi及其同事在BMC Biology上发表的一篇论文揭示了Klf5调节多能性的机制。参见研究文章http://www.biomedcentral.com/1741-7007/8/128
Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency. See research article http://www.biomedcentral.com/1741-7007/8/128
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