The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
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DOI：
10.1186/1471-2458-8-400
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发表时间：
2008-12-05
影响因子：
4.5
通讯作者：
Abbas, K. A.
中科院分区：
文献类型：
--
作者：
Abdulamir, A. S.;Hafidh, R. R.;Abdulmuhaimen, N.;Abubakar, F.;Abbas, K. A.
鼻咽癌（Nasopharyngeal carcinoma，NPC）和其他头颈部癌（head and neck cancer，HNCA）在世界不同地区的流行病学差异很大。鼻咽癌的病因是多因素的，许多相互作用的危险因素参与了鼻咽癌的发展，主要是Epstein巴尔病毒（EBV）。有必要仔细研究影响NPC的复杂风险因素网络，以及它们与其他HNCA类型的不同程度。在中东地区对122名HNCA患者和100名对照受试者进行了研究。我们的研究涉及三种类型的HNCA，NPC，喉癌（CL）和下咽癌（HPC）。研究的危险因素包括EB病毒血清IgG和伊加抗体水平，年龄，性别，吸烟，饮酒，组织学和疾病家族史。鼻咽癌组血清EB病毒IgG、伊加抗体水平明显高于CL组、HPC组和对照组（P < 0.01）。NPC与淋巴上皮瘤（LE）、男性、经常饮酒和经常吸烟有关，而CL和HPC则无关（p < 0.05）。CL和HPC与SCC肿瘤相关（p < 0.05）。此外，NPC与CL和HPC组不同，不受HNCA阳性家族史的影响（p > 0.05）。LE肿瘤组、常吸烟组、年轻组和家族史阴性组血清EBV IgG和伊加抗体水平分别高于SCC肿瘤组、非常吸烟组、老年组和家族史阳性组（p < 0.05），而常饮酒组则无明显差异（p > 0.05）。提示鼻咽癌的危险因素与其他高危人群的危险因素有较大差异。EBV、吸烟、饮酒、LE肿瘤、男性患者、年龄> 54岁是鼻咽癌的高危因素，而SCC和阳性家族史不是鼻咽癌的高危因素。鼻咽癌患者的早期发病率、吸烟、LE肿瘤和阴性家族史与EBV明显相关。因此，正确确定鼻咽癌的危险因素，对正确划分鼻咽癌的危险人群至关重要，有助于鼻咽癌的早期发现和筛查。
Nasopharyngeal carcinoma (NPC) and other head and neck cancer (HNCA) types show a great epidemiological variation in different regions of the world. NPC has multifactorial etiology and many interacting risk factors are involved in NPC development mainly Epstein Barr virus (EBV). There is a need to scrutinize the complicated network of risk factors affecting NPC and how far they are different from that of other HNCA types. 122 HNCA patients and 100 control subjects were studied in the region of the Middle East. Three types of HNCA were involved in our study, NPC, carcinoma of larynx (CL), and hypopharyngeal carcinoma (HPC). The risk factors studied were the level of EBV serum IgG and IgA antibodies measured by ELISA, age, sex, smoking, alcohol intake, histology, and family history of the disease. EBV serum level of IgG and IgA antibodies was higher in NPC than CL, HPC, and control groups (p < 0.01). NPC was associated with lymphoepithelioma (LE) tumors, males, regular alcohol intake, and regular smoking while CL and HPC were not (p < 0.05). CL and HPC were associated with SCC tumors (p < 0.05). Furthermore, NPC, unlike CL and HPC groups, was not affected by the positive family history of HNCA (p > 0.05). The serum levels of EBV IgG and IgA antibodies were higher in LE tumors, regular smokers, younger patients, and negative family history groups of NPC patients than SCC tumors, non-regular smokers, older patients and positive family history groups respectively (p < 0.05) while this was not found in the regular alcoholics (p > 0.05). It was concluded that risk factors of NPC deviate much from that of other HNCA. EBV, smoking, alcohol intake, LE tumors, male patient, and age > 54 years were hot risk factors of NPC while SCC and positive family history of the disease were not. Earlier incidence, smoking, LE tumors, and negative family history of the disease in NPC patients were associated much clearly with EBV. It is proposed that determining the correct risk factors of NPC is vital in assigning the correct risk groups of NPC which helps the early detection and screening of NPC.
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影响因子：
5.7
作者：
Erkal, HS;Serin, M;Çakmak, A
通讯作者：
Çakmak, A
影响因子：
6.4
作者：
Chan, KH;Gu, YL;Ng, MH
通讯作者：
Ng, MH
DOI：
10.1631/jzus.2004.1304
发表时间：
2004-10-01
期刊：
Journal of Zhejiang University. Science
影响因子：
--
作者：
Tang, Jian-Guo;Li, Xuan;Chen, Ping
通讯作者：
Chen, Ping
DOI：
10.1016/s0360-3016(00)00558-7
发表时间：
2000-07-01
影响因子：
7
作者：
Cooper, JS;Lee, H;Hochster, H
通讯作者：
Hochster, H
影响因子：
50.5
作者：
Ou, S. -H. I.;Zell, J. A.;Anton-Culver, H.
通讯作者：
Anton-Culver, H.