Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations.
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations.
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DOI：
10.3390/cells10020386
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发表时间：
2021-02-13
期刊：
影响因子：
6
通讯作者：
Pulliam L
中科院分区：
文献类型：
--
作者：
Sun B;Tang N;Peluso MJ;Iyer NS;Torres L;Donatelli JL;Munter SE;Nixon CC;Rutishauser RL;Rodriguez-Barraquer I;Greenhouse B;Kelly JD;Martin JN;Deeks SG;Henrich TJ;Pulliam L
随着SARS-CoV-2大流行的持续，报告显示COVID-19康复后出现神经系统后遗症。解释长期神经系统后遗症的机制尚不清楚，需要确定。收集了24名在初次感染后1至3个月从COVID-19中康复的个体的血浆，用于细胞因子和抗体水平以及富含神经元的细胞外囊泡（nEV）蛋白质货物分析。所有COVID-19参与者的血浆细胞因子IL-4均升高。与没有神经系统问题的COVID-19个体（CoV，n = 16）相比，自我报告有神经系统问题的志愿者（nCoV，n = 8）的IL 6与年龄或后遗症严重程度、至少一种共病和SARS-CoV-2抗体增加呈正相关。与历史对照组相比，所有从COVID-19中恢复的参与者的nEV中神经元功能障碍的蛋白质标志物，包括淀粉样蛋白β、神经丝光、神经颗粒蛋白、总tau和p-T181-tau，都显著增加。这项研究表明，COVID-19感染后持续的外周和神经炎症可能通过改变nEV蛋白影响神经系统后遗症。从COVID-19中恢复的个体可能有隐匿性神经损伤，而那些有明显神经症状的人则有更严重的感染。监测血浆生物标志物和nEV货物的纵向研究是必要的，以评估持续的神经变性和全身效应。
As the SARS-CoV-2 pandemic continues, reports have demonstrated neurologic sequelae following COVID-19 recovery. Mechanisms to explain long-term neurological sequelae are unknown and need to be identified. Plasma from 24 individuals recovering from COVID-19 at 1 to 3 months after initial infection were collected for cytokine and antibody levels and neuronal-enriched extracellular vesicle (nEV) protein cargo analyses. Plasma cytokine IL-4 was increased in all COVID-19 participants. Volunteers with self-reported neurological problems (nCoV, n = 8) had a positive correlation of IL6 with age or severity of the sequalae, at least one co-morbidity and increased SARS-CoV-2 antibody compared to those COVID-19 individuals without neurological issues (CoV, n = 16). Protein markers of neuronal dysfunction including amyloid beta, neurofilament light, neurogranin, total tau, and p-T181-tau were all significantly increased in the nEVs of all participants recovering from COVID-19 compared to historic controls. This study suggests ongoing peripheral and neuroinflammation after COVID-19 infection that may influence neurological sequelae by altering nEV proteins. Individuals recovering from COVID-19 may have occult neural damage while those with demonstrative neurological symptoms additionally had more severe infection. Longitudinal studies to monitor plasma biomarkers and nEV cargo are warranted to assess persistent neurodegeneration and systemic effects.
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影响因子：
12.3
作者：
Huang, Da Wei;Sherman, Brad T;Tan, Qina;Collins, Jack R;Alvord, W Gregory;Roayaei, Jean;Stephens, Robert;Baseler, Michael W;Lane, H Clifford;Lempicki, Richard A
通讯作者：
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DOI：
10.1016/j.ijid.2020.10.044
发表时间：
2021-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
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作者：
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通讯作者：
Silva MTT
影响因子：
82.9
作者：
Del Valle DM;Kim-Schulze S;Huang HH;Beckmann ND;Nirenberg S;Wang B;Lavin Y;Swartz TH;Madduri D;Stock A;Marron TU;Xie H;Patel M;Tuballes K;Van Oekelen O;Rahman A;Kovatch P;Aberg JA;Schadt E;Jagannath S;Mazumdar M;Charney AW;Firpo-Betancourt A;Mendu DR;Jhang J;Reich D;Sigel K;Cordon-Cardo C;Feldmann M;Parekh S;Merad M;Gnjatic S
通讯作者：
Gnjatic S
影响因子：
9.9
作者：
Lin, Chin-Hsien;Li, Cheng-Hsuan;Chiu, Ming-Jang
通讯作者：
Chiu, Ming-Jang
影响因子：
5.3
作者：
Goetzl EJ;Boxer A;Schwartz JB;Abner EL;Petersen RC;Miller BL;Carlson OD;Mustapic M;Kapogiannis D
通讯作者：
Kapogiannis D