Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.
Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.
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DOI：
10.1002/chem.201602298
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发表时间：
2016-11-21
期刊：
影响因子：
--
通讯作者：
Weil T
中科院分区：
文献类型：
--
作者：
Kuan SL;Wang T;Weil T
The synthetic transformation of polypeptides with molecular accuracy holds great promise for providing functional and structural diversity beyond the proteome. Consequently, the last decade has seen an exponential growth of site‐directed chemistry to install additional features into peptides and proteins even inside living cells. The disulfide rebridging strategy has emerged as a powerful tool for site‐selective modifications since most proteins contain disulfide bonds. In this Review, we present the chemical design, advantages and limitations of the disulfide rebridging reagents, while summarizing their relevance for synthetic customization of functional protein bioconjugates, as well as the resultant impact and advancement for biomedical applications.
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DOI：
10.1039/c3cc45220d
发表时间：
2013-09-25
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Castañeda L;Maruani A;Schumacher FF;Miranda E;Chudasama V;Chester KA;Baker JR;Smith ME;Caddick S
通讯作者：
Caddick S
影响因子：
8.4
作者：
Akkapeddi P;Azizi SA;Freedy AM;Cal PMSD;Gois PMP;Bernardes GJL
通讯作者：
Bernardes GJL
影响因子：
2.7
作者：
Bouchard, Herve;Viskov, Christian;Garcia-Echeverria, Carlos
通讯作者：
Garcia-Echeverria, Carlos
DOI：
10.1155/2013/926295
发表时间：
2013
期刊：
International journal of peptides
影响因子：
--
作者：
Barbieri F;Bajetto A;Pattarozzi A;Gatti M;Würth R;Thellung S;Corsaro A;Villa V;Nizzari M;Florio T
通讯作者：
Florio T
影响因子：
4.7
作者：
Bryden, Francesca;Maruani, Antoine;Boyle, Ross W.
通讯作者：
Boyle, Ross W.