Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep.
Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep.
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十二指肠5-羟色氨酸灌注对绵羊胃肠道褪黑激素合成的影响
DOI：
10.3390/molecules26175275
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发表时间：
2021-08-31
期刊：
影响因子：
--
通讯作者：
Yang K
中科院分区：
文献类型：
--
作者：
Pan J;Li F;Wang C;Li X;Zhang S;Zhang W;Zhao G;Ma C;Liu G;Yang K
本研究的目的是探讨 5-羟色氨酸 (5-HTP) 十二指肠灌注对绵羊胃肠道 (GI) 褪黑激素 (MT) 合成的潜在影响。 5-羟基色氨酸是褪黑激素合成途径的前体。结果表明，该方法显着增加了胃肠道所有节段（包括十二指肠、空肠、回肠、盲肠和结肠）粘膜中褪黑激素的产生。结肠中的褪黑激素水平最高，这表明结肠中的微生物群也可能参与褪黑激素的产生。此外，胃肠道产生的部分褪黑激素可通过肝脏代谢，经门静脉进入循环。目前的研究提供了进一步的证据支持胃肠道是褪黑激素合成的主要部位，并且胃肠道褪黑激素也有助于循环褪黑激素水平，因为5-HTP治疗组的血浆褪黑激素浓度显着高于对照组。总之，结果表明，6小时内流入十二指肠的10-50 mg 5-HTP可有效提高胃肠道褪黑激素的产生以及羊白天血液循环中褪黑激素的浓度。
The purpose of this study is to investigate the potential effects of 5-hydroxytryptophan (5-HTP) duodenal perfusion on melatonin (MT) synthesis in the gastrointestinal (GI) tract of sheep. 5-hydroxytryptophan is a precursor in the melatonin synthetic pathway. The results showed that this method significantly increased melatonin production in the mucosa of all segments in GI tract including duodenum, jejunum, ileum, cecum and colon. The highest melatonin level was identified in the colon and this indicates that the microbiota located in the colon may also participate in the melatonin production. In addition, portion of the melatonin generated by the GI tract can pass the liver metabolism and enters the circulation via portal vein. The current study provides further evidence to support that GI tract is the major site for melatonin synthesis and the GI melatonin also contributes to the circulatory melatonin level since plasma melatonin concentrations in 5-HTP treated groups were significantly higher than those in the control group. In conclusion, the results show that 10–50 mg of 5-HTP flowing into the duodenum within 6 h effectively improve the production of melatonin in the GI tract and melatonin concentration in sheep blood circulation during the day.
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