The effects for inflammatory responses by CPP with different colloidal properties in hemodialysis patients.
The effects for inflammatory responses by CPP with different colloidal properties in hemodialysis patients.
复制标题
DOI：
10.1038/s41598-022-26166-2
复制
发表时间：
2022-12-17
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
钙蛋白颗粒（CPPs）是由固相磷酸钙和血清蛋白胎球蛋白A组成的胶体。CPP形成具有不同粒径和密度的多分散体系。具有特定物理性质的CPP可以在培养的细胞中诱导钙化和先天免疫反应。在血液透析患者中，血液CPP水平与血管钙化和炎症相关。然而，很少有人知道这些疾病和CPP的物理性质之间的关系。在这里，我们显示了78例血液透析门诊患者的血浆CPPs的物理性质和血清炎症细胞因子/趋化因子水平之间的关系，通过横断面研究。心血管疾病（CVD）患者的高密度CPP（H-CPP）水平显着高于无CVD的患者，但不低密度CPP（L-CPP）。在> 95%的患者血清样品中可检测到7种细胞因子/趋化因子（EGF、eotaxin、IL-8、IP-10、MCP-1、MIP-1、MIP-1β和TNFα）。在多变量回归分析中，在调整年龄、性别、吸烟、血清磷酸盐和FGF 23后，H-CPP与eotaxin呈正相关。在调整年龄、性别、血清白蛋白、磷酸盐和FGF 23后，L-CPP与IL-8呈负相关。高H-CPP水平与促炎反应相关，而L-CPP与抗炎反应相关。具有不同物理性质的CPP可能对HD患者的病理生理学产生不同的影响。
Calciprotein particles (CPPs) are colloids composed of solid-phase calcium-phosphate and serum protein fetuin-A. CPPs form a polydispersed system with different particle size and density. CPPs with specific physical properties can induce calcification and innate immune responses in cultured cells. In hemodialysis patients, blood CPP levels were reported to correlate with vascular calcification and inflammation. However, little is known about relation between these disorders and physical properties of CPPs. Here, we show that the association between physical properties of plasma CPPs and serum levels of inflammatory cytokines/chemokines in 78 hemodialysis out-patients by cross-sectional study. Patients with cardiovascular disease (CVD) had significantly higher high density CPP (H-CPP) levels than patients without CVD but not low density CPP (L-CPP). Seven cytokines/chemokines (EGF, eotaxin, IL-8, IP-10, MCP-1, MIP-1, MIP-1β and TNFα) were detectable in the serum samples from > 95% of the patients. In multivariate regression analysis, H-CPP was positively associated with eotaxin after adjusting for age, gender, smoking, serum phosphate and FGF23. L-CPP was negatively associated with IL-8 after adjusting for age, gender, serum albumin, phosphate and FGF23. High H-CPP levels were associated with pro-inflammatory response, whereas L-CPPs were associated with anti-inflammatory response. CPPs with different physical properties may impact differently on pathophysiology in HD patients.
登录
查看更多内容
影响因子：
--
作者：
Panichi, V;Taccola, D;Tetta, C
通讯作者：
Tetta, C
影响因子：
4.8
作者：
Heiss, A;DuChesne, A;Jahnen-Dechent, W
通讯作者：
Jahnen-Dechent, W
影响因子：
19.6
作者：
Narita, I;Alchi, B;Gejyo, F
通讯作者：
Gejyo, F
影响因子：
19.6
作者：
Keithi-Reddy, S. R.;Patel, T. V.;Singh, A. K.
通讯作者：
Singh, A. K.
影响因子：
5.3
作者：
Gatate, Yodo;Nakano, Shintaro;Kuro-o, Makoto
通讯作者：
Kuro-o, Makoto