The association between gut microbiota and postoperative delirium in patients.
The association between gut microbiota and postoperative delirium in patients.
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肠道菌群与患者术后谵妄之间的关系。
DOI：
10.1038/s41398-023-02450-1
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发表时间：
2023-05-09
影响因子：
6.8
通讯作者：
Xie, Zhongcong
中科院分区：
文献类型：
--
作者：
Zhang, Yiying;Baldyga, Kathryn;Dong, Yuanlin;Song, Wenyu;Villanueva, Mirella;Deng, Hao;Mueller, Ariel;Houle, Timothy T.;Marcantonio, Edward R.;Xie, Zhongcong
术后谵妄是老年患者常见的术后并发症，其发病机制和生物标志物在很大程度上仍不确定。肠道微生物群已被证明可以调节大脑功能，因此，探索肠道微生物群与术后谵妄之间的关系至关重要。在220名在全身麻醉或脊髓麻醉下接受膝关节置换术、髋关节置换术或椎板切除术的患者（65岁或以上）中，86名参与者被纳入数据分析。术后谵妄的发生率（主要结局）和严重程度评估两天。手术后立即采集受试者的粪便拭子。16 S rRNA基因测序用于评估肠道微生物群。主成分分析沿着文献综述用于识别合理的肠道微生物群，并进一步研究了三种肠道细菌与术后谵妄的相关性。在86名参与者[年龄71.0（69.0-76.0，25-75%四分位数百分位数），53%女性]中，10名（12%）发生术后谵妄。在调整年龄和性别后，术后肠道细菌Distasonis副拟杆菌与术后谵妄相关（比值比[OR] 2.13，95%置信区间（CI）：1.09-4.17，P = 0.026）。谵妄与普雷沃菌（OR：0.59，95%CI：0.33-1.04，P = 0.067）和柯林斯菌（OR：0.57，95%CI：0.27-1.24，P = 0.158）的相关性未达到统计学显著性。这些发现表明，术后肠道微生物群，特别是Distasonis副拟杆菌，与术后谵妄之间可能存在关联。然而，需要进一步的研究来证实这些发现，并更好地了解肠-脑轴在术后结局中的作用。
Postoperative delirium is a common postoperative complication in older patients, and its pathogenesis and biomarkers remain largely undetermined. The gut microbiota has been shown to regulate brain function, and therefore, it is vital to explore the association between gut microbiota and postoperative delirium. Of 220 patients (65 years old or older) who had a knee replacement, hip replacement, or laminectomy under general or spinal anesthesia, 86 participants were included in the data analysis. The incidence (primary outcome) and severity of postoperative delirium were assessed for two days. Fecal swabs were collected from participants immediately after surgery. The 16S rRNA gene sequencing was used to assess gut microbiota. Principal component analyses along with a literature review were used to identify plausible gut microbiota, and three gut bacteria were further studied for their associations with postoperative delirium. Of the 86 participants [age 71.0 (69.0–76.0, 25–75% percentile of quartile), 53% female], 10 (12%) developed postoperative delirium. Postoperative gut bacteria Parabacteroides distasonis was associated with postoperative delirium after adjusting for age and sex (Odds Ratio [OR] 2.13, 95% Confidence Interval (CI): 1.09–4.17, P = 0.026). The association between delirium and both Prevotella (OR: 0.59, 95% CI: 0.33–1.04, P = 0.067) and Collinsella (OR: 0.57, 95% CI: 0.27–1.24, P = 0.158) did not meet statistical significance. These findings suggest that there may be an association between postoperative gut microbiota, specifically Parabacteroides distasonis, and postoperative delirium. However, further research is needed to confirm these findings and better understand the gut-brain axis’s role in postoperative outcomes.
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影响因子：
120.7
作者：
Marcantonio, Edward R.
通讯作者：
Marcantonio, Edward R.
适当的运动水平可减轻肠道菌群失调和戊酸增加，从而改善小鼠手术后的神经可塑性和认知功能
影响因子：
11
作者：
Lai Z;Shan W;Li J;Min J;Zeng X;Zuo Z
通讯作者：
Zuo Z
影响因子：
4.7
作者：
Breitbart, W;Rosenfeld, B;Passik, S
通讯作者：
Passik, S
DOI：
10.1111/j.1532-5415.2000.tb04718.x
发表时间：
2000-06-01
影响因子：
6.3
作者：
Marcantonio, ER;Flacker, JM;Resnick, NM
通讯作者：
Resnick, NM
DOI：
10.1046/j.1532-5415.2002.50210.x
发表时间：
2002-05-01
影响因子：
6.3
作者：
Marcantonio, E;Ta, T;Resnick, NM
通讯作者：
Resnick, NM