Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice.
Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice.
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适当的运动水平可减轻肠道菌群失调和戊酸增加，从而改善小鼠手术后的神经可塑性和认知功能
DOI：
10.1038/s41380-021-01291-y
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发表时间：
2021-12
影响因子：
11
通讯作者：
Zuo Z
中科院分区：
文献类型：
--
作者：
Lai Z;Shan W;Li J;Min J;Zeng X;Zuo Z
术后认知功能障碍（POCD）每年影响数百万患者的预后。衰老是POCD的危险因素。在这里，我们发现手术引起成年小鼠的学习和记忆功能障碍。移植手术小鼠的粪便而不是对照小鼠的粪便会导致非手术小鼠的学习和记忆障碍。低强度运动改善了手术小鼠的学习和记忆。运动减轻手术引起的神经炎症和肠道微生物群多样性的减少。这些运动效应出现在接受运动小鼠粪便的非运动小鼠身上。运动减少了血液中的一种肠道微生物产物——戊酸。戊酸恶化了手术小鼠的神经炎症、学习和记忆。运动的下游效应包括减缓生长因子的减少，维持星形胶质细胞A2表型形式，可能通过减少C3信号和改善神经可塑性。与成年小鼠的结果相似，运动减轻了手术后老年小鼠的学习和记忆障碍。接受老年运动小鼠粪便的老年小鼠比接受对照组小鼠粪便的老年小鼠具有更好的学习和记忆能力。手术增加了血戊酸。戊酸阻断运动对老年手术小鼠学习和记忆的影响。运动稳定了老年手术小鼠的肠道微生物群，减少了神经炎症，减轻了生长因子的减少，并保留了神经可塑性。这些结果为肠道菌群的改变有助于POCD的发展提供了直接证据。戊酸是这种效应的中介，也是大脑健康的潜在目标。低强度的运动可以稳定肠道微生物群，比如手术。
Postoperative cognitive dysfunction (POCD) affects the outcome of millions of patients each year. Aging is a risk factor for POCD. Here, we showed that surgery induced learning and memory dysfunction in adult mice. Transplantation of feces from surgery mice but not from control mice led to learning and memory impairment in non-surgery mice. Low intensity exercise improved learning and memory in surgery mice. Exercise attenuated surgery-induced neuroinflammation and decrease of gut microbiota diversity. These exercise effects were present in non-exercise mice receiving feces from exercise mice. Exercise reduced valeric acid, a gut microbiota product, in the blood. Valeric acid worsened neuroinflammation, learning and memory in exercise mice with surgery. The downstream effects of exercise included attenuating growth factor decrease, maintaining astrocytes in the A2 phenotypical form possibly via decreasing C3 signaling and improving neuroplasticity. Similar to these results from adult mice, exercise attenuated learning and memory impairment in old mice with surgery. Old mice receiving feces from old exercise mice had better learning and memory than those receiving control old mouse feces. Surgery increased blood valeric acid. Valeric acid blocked exercise effects on learning and memory in old surgery mice. Exercise stabilized gut microbiota, reduced neuroinflammation, attenuated growth factor decrease and preserved neuroplasticity in old mice with surgery. These results provide direct evidence that gut microbiota alteration contributes to POCD development. Valeric acid is a mediator for this effect and a potential target for brain health. Low intensity exercise stabilizes gut microbiota in the presence of insult, such as surgery.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
影响因子：
4.7
作者：
Gui, Lingli;Lei, Xi;Zuo, Zhiyi
通讯作者：
Zuo, Zhiyi
影响因子：
14.8
作者：
Leger, Marianne;Quiedeville, Anne;Freret, Thomas
通讯作者：
Freret, Thomas
手术创伤严重程度而非麻醉时间会导致小鼠术后认知功能障碍
影响因子：
4
作者：
Lai, Zhongmeng;Min, Jia;Zuo, Zhiyi
通讯作者：
Zuo, Zhiyi