ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls.
ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls.
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DOI：
10.1007/s00586-023-07542-6
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发表时间：
2023-05
影响因子：
2.8
通讯作者：
Fields, Aaron J.
中科院分区：
文献类型：
--
作者：
Bonnheim, Noah B.;Lazar, Ann A.;Kumar, Anika;Akkaya, Zehra;Zhou, Jiamin;Guo, Xiaojie;O'Neill, Conor;Link, Thomas M.;Lotz, Jeffrey C.;Krug, Roland;Fields, Aaron J.
关键词：
慢性下腰痛（cLBP）患者椎间盘退变的临床管理受到区分疼痛相关病理变化和衰老相关生理变化的挑战的阻碍。本研究的目的是使用椎间盘生物化学成分的成像生物标志物来区分与正常老化相关的cLBP的退行性变化。从本观察性研究的133例前瞻性入组受试者中采集T1ρ MRI数据（80例cLBP，53例对照;平均值± SD年龄= 43.9 ± 13.4岁; 61例女性，72例男性）。髓核中的平均T1ρ弛豫时间（NP-T1ρ; n = 650个椎间盘）用作椎间盘生化成分的定量生物标志物。线性回归用于评估NP-T1ρ与年龄、性别、脊柱节段和研究组之间的相关性及其相互作用。cLBP患者的NP-T1ρ值低于对照组（70.8 ± 22.8 vs. 76.4 ± 22.2 ms，p = 0.009）。组间差异在L5-S1最大（p < 0.0001），代表在9-12年期间通常观察到的生化恶化（NP-T1ρ每年下降0.8-1.1 ms [95% CI]）。年轻患者的组间差异较大，并随年龄增长而减小。最后，对照组椎间盘退变的年龄依赖性强于cLBP患者。对L5-S1椎间盘生化成分的衰老效应可能涉及一组相对统一的因素，许多cLBP患者偏离这些因素。L5-S1的NP-T1ρ值可能与临床表型高度相关，特别是在年轻个体中。
Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related to aging. The goal of this study was to use imaging biomarkers of disc biochemical composition to distinguish degenerative changes associated with cLBP from normal aging. T1ρ MRI data were acquired from 133 prospectively enrolled subjects for this observational study (80 cLBP, 53 controls; mean ± SD age = 43.9 ± 13.4 years; 61 females, 72 males). The mean T1ρ relaxation time in the nucleus pulposus (NP-T1ρ; n = 650 discs) was used as a quantitative biomarker of disc biochemical composition. Linear regression was used to assess associations between NP-T1ρ and age, sex, spinal level, and study group, and their interactions. NP-T1ρ values were lower in cLBP patients than controls (70.8 ± 22.8 vs. 76.4 ± 22.2 ms, p = 0.009). Group differences were largest at L5–S1 (, p < 0.0001), representing biochemical deterioration typically observed over a 9–12 year period (NP-T1ρ declined by 0.8–1.1 ms per year [95% CI]). Group differences were large in younger patients and diminished with age. Finally, the age-dependence of disc degeneration was stronger in controls than cLBP patients. Aging effects on the biochemical composition of the L5–S1 disc may involve a relatively uniform set of factors from which many cLBP patients deviate. NP-T1ρ values at L5–S1 may be highly relevant to clinical phenotyping, particularly in younger individuals.
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影响因子：
2.4
作者：
Urban, Jill P. G.;Fairbank, Jeremy C. T.
通讯作者：
Fairbank, Jeremy C. T.
影响因子：
3
作者：
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影响因子：
2.8
作者：
Bonnheim, Noah B.;Wang, Linshanshan;Lazar, Ann A.;Zhou, Jiamin;Chachad, Ravi;Sollmann, Nico;Guo, Xiaojie;Iriondo, Claudia;O'Neill, Conor;Lotz, Jeffrey C.;Link, Thomas M.;Krug, Roland;Fields, Aaron J.
通讯作者：
Fields, Aaron J.
影响因子：
3.3
作者：
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通讯作者：
Majumdar, Sharmila
影响因子：
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作者：
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通讯作者：
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