The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain.
The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain.
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软骨终板成分和椎体骨髓脂肪对慢性腰痛患者椎间盘退变的影响
DOI：
10.1007/s00586-022-07206-x
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发表时间：
2022-07
影响因子：
2.8
通讯作者：
Fields, Aaron J.
中科院分区：
文献类型：
--
作者：
Bonnheim, Noah B.;Wang, Linshanshan;Lazar, Ann A.;Zhou, Jiamin;Chachad, Ravi;Sollmann, Nico;Guo, Xiaojie;Iriondo, Claudia;O'Neill, Conor;Lotz, Jeffrey C.;Link, Thomas M.;Krug, Roland;Fields, Aaron J.
关键词：
软骨下骨髓和软骨终板（CEP）的组成可以通过影响椎体灌注和营养扩散来影响椎间盘健康。然而，这些因素对慢性腰痛（cLBP）患者椎间盘退变的相对作用尚未量化。本研究的目的是使用来自定量MRI的成分生物标志物来确定CEP成分（渗透性替代品）和椎体骨髓脂肪分数（BMFF，灌注替代品）与椎间盘退变的关系。本前瞻性观察性研究纳入了60例cLBP患者的MRI数据（28例女性，32例男性;年龄= 40.0 ± 11.9岁，19-65 [平均值± SD，最小值-最大值]）。使用超短回波时间MRI计算CEP T2* 弛豫时间（反映生化成分），使用水-脂肪MRI计算椎体BMFF，使用T1ρ MRI计算髓核T1ρ弛豫时间（NP T1ρ，反映蛋白多糖含量和退行性分级）。使用单变量线性回归评估CEP T2* 和椎骨BMFF对NP T1ρ的独立影响。考虑年龄、性别和BMI的混合效应多变量线性回归用于评估变量之间的组合关系。CEP T2* 和椎体BMFF与NP T1ρ独立相关（分别为p = 0.003和0.0001）。校正年龄、性别和BMI后，NP T1ρ与CEP T2*（p = 0.0001）仍显著相关，但与椎骨BMFF无关（p = 0.43）。CEP组成不良在椎间盘退变严重程度中起重要作用，并且在有或没有椎体灌注缺陷的情况下都可能影响椎间盘健康。 在线版本包含补充材料，可通过10.1007/s 00586 -022-07206-x获得。
The composition of the subchondral bone marrow and cartilage endplate (CEP) could affect intervertebral disc health by influencing vertebral perfusion and nutrient diffusion. However, the relative contributions of these factors to disc degeneration in patients with chronic low back pain (cLBP) have not been quantified. The goal of this study was to use compositional biomarkers derived from quantitative MRI to establish how CEP composition (surrogate for permeability) and vertebral bone marrow fat fraction (BMFF, surrogate for perfusion) relate to disc degeneration. MRI data from 60 patients with cLBP were included in this prospective observational study (28 female, 32 male; age = 40.0 ± 11.9 years, 19–65 [mean ± SD, min–max]). Ultra-short echo-time MRI was used to calculate CEP T2* relaxation times (reflecting biochemical composition), water-fat MRI was used to calculate vertebral BMFF, and T1ρ MRI was used to calculate T1ρ relaxation times in the nucleus pulposus (NP T1ρ, reflecting proteoglycan content and degenerative grade). Univariate linear regression was used to assess the independent effects of CEP T2* and vertebral BMFF on NP T1ρ. Mixed effects multivariable linear regression accounting for age, sex, and BMI was used to assess the combined relationship between variables. CEP T2* and vertebral BMFF were independently associated with NP T1ρ (p = 0.003 and 0.0001, respectively). After adjusting for age, sex, and BMI, NP T1ρ remained significantly associated with CEP T2* (p = 0.0001) but not vertebral BMFF (p = 0.43). Poor CEP composition plays a significant role in disc degeneration severity and can affect disc health both with and without deficits in vertebral perfusion. The online version contains supplementary material available at 10.1007/s00586-022-07206-x.
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DOI：
10.1002/jor.24787
发表时间：
2021-07
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Wang L;Han M;Wong J;Zheng P;Lazar AA;Krug R;Fields AJ
通讯作者：
Fields AJ
影响因子：
3.7
作者：
Dolor, Aaron;Sampson, Sara L.;Fields, Aaron J.
通讯作者：
Fields, Aaron J.
影响因子：
19.7
作者：
Fields, Aaron J.;Han, Misung;Lotz, Jeffrey C.
通讯作者：
Lotz, Jeffrey C.
影响因子：
3.3
作者：
Gurney, PT;Hargreaves, BA;Nishimura, DG
通讯作者：
Nishimura, DG
影响因子：
2.4
作者：
Urban, Jill P. G.;Fairbank, Jeremy C. T.
通讯作者：
Fairbank, Jeremy C. T.