Left Ventricular Segmental Strain Identifies Unique Myocardial Deformation Patterns After Intrinsic and Extrinsic Stressors in Mice.
Left Ventricular Segmental Strain Identifies Unique Myocardial Deformation Patterns After Intrinsic and Extrinsic Stressors in Mice.
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DOI：
10.1016/j.ultrasmedbio.2022.06.004
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发表时间：
2022-10
影响因子：
2.9
通讯作者：
Chantler, Paul D.
中科院分区：
文献类型：
--
作者：
Kunovac, A. M. I. N. A.;Hathaway, Quincy A.;Burrage, Emily N.;Coblentz, T. Y. L. E. R.;Kelley, Eric E.;Sengupta, Partho P.;Hollander, John M.;Chantler, Paul D.
我们利用节段应变分析来评估内在（饮食诱发的肥胖（DIO））和外在（不可预测的慢性轻度应激（UCMS））压力源是否可以改变左心室的变形模式。 6 周龄雄性 C57BL/6J 小鼠被随机分为瘦组或肥胖组（N = 24/组）。小鼠接受 12 周的 DIO 和高脂肪饮食 (HFD)。第 18 周时，瘦小鼠和肥胖小鼠被进一步随机分为 UCMS 组和非 UCMS 组（UCMS；每天 7 小时，每周 5 天，持续 8 周）。在基线（6周）、HFD后（18周）和UCMS后（26周）进行超声心动图检查。机器学习应用于 DIO 和 UCMS 组。当比较肥胖小鼠和瘦小鼠时，具有稳健的预测准确性（AUC：0.921），外侧壁（−64％，P≤0.001）和前游离壁（−53％，P<0.001）的径向应变变化最具信息性。评估了预测接受 UCMS 的小鼠的能力，无论饮食如何（AUC：0.886），显示前中壁的纵向应变率和后间隔壁的径向应变是主要特征。壁段表明游离壁（DIO）和间隔壁（UCMS）变形模式变化的倾向，表明心肌的疾病特异性改变。
We utilized segmental strain analysis to evaluate whether intrinsic (diet-induced obesity (DIO)) and extrinsic (unpredictable chronic mild stress (UCMS)) stressors can alter deformational patterns of the left ventricle. 6-week-old, male C57BL/6J mice were randomized into lean or obese groups (N = 24/group). Mice underwent 12 weeks of DIO with a high-fat diet (HFD). At 18 weeks, lean and obese mice were further randomized into UCMS and non-UCMS groups (UCMS; 7 hrs/day, 5 days/week, for 8 weeks). Echocardiography was performed at baseline (6 weeks), post-HFD (18 weeks), and post-UCMS (26 weeks). Machine learning was applied to the DIO and UCMS groups. There was robust predictive accuracy (AUC: 0.921) when comparing obese to lean mice with radial strain changes in the lateral (−64%, P≤0.001) and anterior free (−53%, P<0.001) walls being most informative. The ability to predict mice that underwent UCMS, irrespective of diet, was assessed (AUC: 0.886) revealing longitudinal strain rate of the anterior mid wall and radial strain of the posterior septal wall as the top features. The wall segments indicate a predilection for changes in deformation patterns to the free wall (DIO) and septal wall (UCMS), indicating disease-specific alterations to the myocardium.
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影响因子：
6.3
作者：
Alsharqi M;Woodward WJ;Mumith JA;Markham DC;Upton R;Leeson P
通讯作者：
Leeson P
影响因子：
1.9
作者：
Saccheri MC;Cianciulli TF;Morita LA;Méndez RJ;Beck MA;Guerra JE;Cozzarin A;Puente LJ;Balletti LR;Lax JA
通讯作者：
Lax JA
DOI：
10.1007/978-1-4419-7390-0_8
发表时间：
2011-01-01
期刊：
PREDICTIVE SPECIES AND HABITAT MODELING IN LANDSCAPE ECOLOOGY: CONCEPTS AND APPLICATIONS
影响因子：
--
作者：
Evans, Jeffrey S.;Murphy, Melanie A.;Cushman, Samuel A.
通讯作者：
Cushman, Samuel A.
DOI：
10.1111/echo.14365
发表时间：
2019-06-01
影响因子：
1.5
作者：
Gupta, Kartik;Kakar, Tanya S.;Bajaj, Navkaranbir S.
通讯作者：
Bajaj, Navkaranbir S.
影响因子：
37.8
作者：
Burchfield JS;Xie M;Hill JA
通讯作者：
Hill JA