Cell biology and pathology of podocytes.
Cell biology and pathology of podocytes.
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DOI：
10.1146/annurev-physiol-020911-153238
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发表时间：
2012
影响因子：
18.2
通讯作者：
Mundel P
中科院分区：
文献类型：
--
作者：
Greka A;Mundel P
作为肾小球滤过屏障的一个组成部分，足细胞处于独特的地理位置：它暴露于来自泌尿空间（鲍曼氏囊）的化学信号，它接收和传递化学和机械信号到/从肾小球基底膜上，它在其上进行加工，并且它接收来自血管空间的化学和机械信号，它也与血管空间通信。与每个细胞一样，足细胞从周围环境接收信号并将其翻译到细胞内环境的能力在很大程度上取决于细胞膜上的分子。这些分子是正在进行的战斗中的第一线士兵，以感知环境，对友好信号做出反应，并抵御有害的敌人。在这篇综述中，我们采取了膜生物学家的观点的足细胞，研究了许多膜受体，通道，和其他信号分子，已牵连在足细胞生物学。虽然我们试图做到全面，但我们的目标不是捕获每一个膜介导的通路，而是强调这种方法可能在理解足细胞及其独特性质方面富有成效。
As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a unique geographical position: It is exposed to chemical signals from the urinary space (Bowman’s capsule), it receives and transmits chemical and mechanical signals to/from the glomerular basement membrane upon which it elaborates, and it receives chemical and mechanical signals from the vascular space with which it also communicates. As with every cell, the ability of the podocyte to receive signals from the surrounding environment and to translate them to the intracellular milieu is dependent largely on molecules residing on the cell membrane. These molecules are the first-line soldiers in the ongoing battle to sense the environment, to respond to friendly signals, and to defend against injurious foes. In this review, we take a membrane biologist’s view of the podocyte, examining the many membrane receptors, channels, and other signaling molecules that have been implicated in podocyte biology. Although we attempt to be comprehensive, our goal is not to capture every membrane-mediated pathway but rather to emphasize that this approach may be fruitful in understanding the podocyte and its unique properties.
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影响因子：
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