Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis- eQTL locus contributing more to the susceptibility of lung cancer.
Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis- eQTL locus contributing more to the susceptibility of lung cancer.
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LncRNA ZNRD1-AS1 及其功能性 Cis-eQTL 位点对肺癌易感性影响更大的有力证据
DOI：
10.18632/oncotarget.8411
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发表时间：
2016-06-14
期刊：
影响因子：
--
通讯作者：
Peng L
中科院分区：
文献类型：
--
作者：
Li D;Song L;Wen Z;Li X;Jie J;Wang Y;Peng L
长链非编码RNA（longnoncodingRNAs，IncRNA）参与肿瘤生物学过程，参与肿瘤细胞的增殖、侵袭和转移等重要功能，近年来受到越来越多的关注。人类锌带结构域1（ZNRD 1）已被证实参与多种癌症的发生和发展。ZNRD 1-AS 1是位于ZNRD 1基因上游的一种lncRNA，可下调ZNRD 1基因的表达，被认为是肿瘤发生的一个可能成分。ZNRD 1-AS 1与肺癌发生、转移的关系尚不清楚。本研究首先检测了ZNRD 1-AS 1和ZNRD 1在肺癌组织和相应正常组织中的表达情况，发现ZNRD 1-AS 1高表达，ZNRD 1低表达。为了揭示潜在的机制，我们随后研究了ZNRD 1-AS 1中ZNRD 1 eQTLs SNPs与中国汉族人群肺癌风险的关系。与A等位基因相比，SNP rs 9261204的G等位基因与肺癌风险增加显著相关（OR：1.45; 95%CI：1.19-1.75; P = 1.06 × 10−4）。在膀胱癌中也观察到较弱但相似的效果。SNP rs3757328也与肺癌风险增加相关（OR：1.34; 95%CI：1.07-1.67; P = 0.011）。我们的研究结果首次证实了LncRNA ZNRD 1-AS 1对亚洲人群肺癌发生的贡献。
Long noncoding RNAs (IncRNAs), involved in cancer biology, contributing to essential cancer cell functions such as proliferation, invasion, and metastasis, have received increasing attention recently. Human Zinc ribbon domain containing 1 (ZNRD1) has been confirmed to be involved in carcinogenesis and development of multiple cancers. ZNRD1-AS1, a lncRNA in the upstream region of ZNRD1 which could down-regulate the expression of ZNRD1, has been identified as a possible component in carcinogenesis. The underlying relations of ZNRD1-AS1 with lung cancer development and metastasis remain obscure. In current study, we first evaluated the expression ZNRD1-AS1 and ZNRD1 among lung cancer tissues and corresponding normal tissues, which showed higher expression of ZNRD1-AS1 and lower expression of ZNRD1. To reveal the underlying mechanisms, we then investigated the associations between ZNRD1 eQTLs SNPs in ZNRD1-AS1 and risk of lung cancer in Han Chinese populations. G allele of SNP rs9261204 was significantly associated with an increased risk of lung cancer when compared with A allele (OR: 1.45; 95% CI: 1.19–1.75; P = 1.06 × 10−4). A weaker, but similar effect was also observed in bladder cancer. SNP rs3757328 was also associated with increased risk of lung cancer (OR: 1.34; 95% CI: 1.07–1.67; P = 0.011). Our findings first confirmed the contribution of LncRNA ZNRD1-AS1 to the development of lung cancer in Asian population.
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影响因子：
3.2
作者：
Maleno, Isabel;Romero, Jose Maria;Garrido, Federico
通讯作者：
Garrido, Federico
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者：
Snyder M
ZNRD1 可能通过调节 ERCC1 介导人食管癌细胞中与紫外线照射相关的 DNA 损伤和修复。
影响因子：
2.6
作者：
Guo, W.;Zhao, Y. -P.;Fan, D. -M.
通讯作者：
Fan, D. -M.
新型 lincRNA AATBC 的敲低可抑制膀胱癌的增殖并诱导细胞凋亡
影响因子：
--
作者：
Zhao, Fengjin;Lin, Tianxin;Xie, Wenlian
通讯作者：
Xie, Wenlian