Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore.
Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore.
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DOI：
10.1186/s12879-020-05546-x
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发表时间：
2020-11-10
影响因子：
3.7
通讯作者：
Ray SC
中科院分区：
文献类型：
--
作者：
Falade-Nwulia O;Hackman J;Mehta SH;McCormick SD;Kirk GD;Sulkowski M;Thomas D;Latkin C;Laeyendecker O;Ray SC
用于治疗丙型肝炎病毒(丙型肝炎病毒)的有效的口服直接作用抗病毒药物(DAA)的可获得性使消除丙型肝炎病毒成为一项触手可及的公共卫生挑战。然而，人们对注射吸毒者(PWID)的传播网络特征知之甚少。对2005年8月至2016年12月期间从PWID社区队列中收集的样本进行了丙型肝炎病毒基因组片段的测序。构建系统发育树，识别聚类(70%自举阈值；0.04最大遗传距离阈值)。我们描述了潜在传播伙伴的性别、种族、年龄差异和艾滋病毒感染状况。Logistic回归被用来评估与丙型肝炎病毒聚集性相关的因素。在5 0 8例丙型肝炎病毒1型中，8%(n= 4 1)分成2 0个聚类群，由19对和1个三联体组成。在调整后的分析中，女性性别(优势比[OR]2.3[95%可信区间(CI)1.2-4.5])和HIV感染(OR 5.7[CI 2.7-11.9])仍然与处于丙型肝炎病毒感染聚集区独立相关。分子流行病学分析显示，在巴尔的摩的这一PWID队列中，HIV感染和女性与丙型肝炎病毒聚集性相关。针对感染艾滋病毒的PWID的丙型肝炎病毒预防干预措施和满足妇女预防丙型肝炎病毒感染的需求相结合，有可能促进消除丙型肝炎病毒的努力。网上版载有补充材料，可在10.1186/s12879-020-05546-x查阅。
The availability of effective, oral direct acting antivirals (DAAs) for hepatitis C virus (HCV) treatment has put elimination of HCV as a public health challenge within reach. However, little is known about the characteristics of transmission networks of people who inject drugs (PWID). Sequencing of a segment of the HCV genome was performed on samples collected from a community-based cohort of PWID between August 2005 and December 2016. Phylogenetic trees were inferred, and clusters were identified (70% bootstrap threshold; 0.04 maximum genetic distance threshold). We describe sex, race, age difference, and HIV infection status of potential transmission partners. Logistic regression was used to assess factors associated with being in an HCV cluster. Of 508 HCV genotype 1 viremic PWID, 8% (n = 41) were grouped into 20 clusters, consisting of 19 pairs and 1 triad. In adjusted analyses, female sex (odds ratio [OR] 2.3 [95% confidence interval (CI) 1.2–4.5]) and HIV infection (OR 5.7 [CI 2.7–11.9]) remained independently associated with being in an HCV infection cluster. Molecular epidemiological analysis reveals that, in this cohort of PWID in Baltimore, HIV infection and female sex were associated with HCV clustering. Combination HCV prevention interventions targeting HIV infected PWID and addressing HCV infection prevention needs of women have potential to advance HCV elimination efforts. The online version contains supplementary material available at 10.1186/s12879-020-05546-x.
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影响因子：
158.5
作者：
Peters, Philip J.;Pontones, Pamela;Duwve, Joan M.
通讯作者：
Duwve, Joan M.
影响因子：
4.4
作者：
Dunn, Matthew;Degenhardt, Louisa;Bruno, Raimondo
通讯作者：
Bruno, Raimondo
影响因子：
3.2
作者：
Bartlett, Sofia R.;Jacka, Brendan;Applegate, Tanya L.
通讯作者：
Applegate, Tanya L.
影响因子：
3.7
作者：
Morris MD;Evans J;Montgomery M;Yu M;Briceno A;Page K;Hahn JA
通讯作者：
Hahn JA
影响因子：
11.8
作者：
Morris, Meghan D.;Shiboski, Stephen;Page, Kimberly
通讯作者：
Page, Kimberly