Intimate injection partnerships are at elevated risk of high-risk injecting: a multi-level longitudinal study of HCV-serodiscordant injection partnerships in San Francisco, CA.
Intimate injection partnerships are at elevated risk of high-risk injecting: a multi-level longitudinal study of HCV-serodiscordant injection partnerships in San Francisco, CA.
复制标题
DOI：
10.1371/journal.pone.0109282
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hahn JA
中科院分区：
文献类型：
--
作者：
Morris MD;Evans J;Montgomery M;Yu M;Briceno A;Page K;Hahn JA
人们越来越认识到，艾滋病毒和丙型肝炎病毒（HCV）在注射吸毒者（PWID）中传播的风险，如共用注射器，发生在（至少）两个人之间的关系中。有证据表明，与注射行为相关的风险因注射伴侣类型而异。我们利用来自旧金山弗朗西斯科（2006年至2013年）的年轻PWID研究的纵向二元水平数据，研究影响HCV血清不一致注射伴侣中高风险注射的关系水平因素（即，前一个月一起注射≥5次的个体）。利用来自70个HCV血清不一致注射伙伴关系的数据，我们使用广义线性模型来检查关系水平的预测因子（即，伙伴关系组成、伙伴关系亲密度和伙伴关系动态）：（1）接受性注射器共享（RSS）;和（2）接受性炊具使用（RCU），如HCV阴性注射伙伴所报告。根据“高危”HCV阴性注射伴侣的报告，接受性注射器共用（RSS）和接受性炊具使用（RCU）在入组时分别为19%和33%，在所有访视中分别为11%和12%（总随访时间为55人-年），导致13例新发HCV感染（发病率：23.8/100人-年）。个人层面的因素，注入伙伴关系的组成，和伙伴关系的动态没有显着相关的RSS或RCU。相反，与仅注射伴侣关系相比，亲密注射伴侣关系（那些生活在一起并且也处于性关系中的人）与RSS的5倍风险和RCU的7倍风险独立相关。我们的研究结果表明，在年轻的PWID注射伙伴关系中，关系因素对注射毒品风险行为有积极的放大效应。减少注射吸毒相关危害的大多数干预措施侧重于以个人为基础的教育，以增加吸毒知识。我们的研究结果支持将减少伤害战略扩展到基于关系的信息传递和干预的必要性。
It is increasingly recognized that the risk for HIV and hepatitis C (HCV) transmission among people who inject drugs (PWID), such as syringe sharing, occurs in the context of relationships between (at least) two people. Evidence suggests that the risk associated with injection behavior varies with injection partner types. We utilized longitudinal dyad-level data from a study of young PWID from San Francisco (2006 to 2013) to investigate the relationship-level factors influencing high-risk injecting within HCV-serodiscordant injection partners (i.e., individuals who injected together ≥5 times in the prior month). Utilizing data from 70 HCV-serodiscordant injection partnerships, we used generalized linear models to examine relationship-level predictors (i.e., partnership composition, partnership closeness, and partnership dynamics) of: (1) receptive syringe sharing (RSS); and (2) receptive cooker use (RCU), as reported by the HCV-negative injection partner. As reported by the “at-risk” HCV-negative injection partner, receptive syringe sharing (RSS) and receptive cooker use (RCU) were 19% and 33% at enrollment, and 11% and 12% over all visits (total follow-up time 55 person-years) resulting in 13 new HCV-infections (incidence rate: 23.8/100 person-years). Person-level factors, injection partnership composition, and partnership dynamics were not significantly associated with either RSS or RCU. Instead, intimate injection partnerships (those who lived together and were also in a sexual relationship) were independently associated with a 5-times greater risk of both RSS and a 7-times greater risk of RCU when compared to injecting only partnerships. Our findings suggest a positive, and amplified effect of relationship factors on injecting drug risk behaviors among young PWID injection partnerships. The majority of interventions to reduce injection drug use related harms focus on individual-based education to increase drug use knowledge. Our findings support the need to expand harm reduction strategies to relationship-based messaging and interventions.
登录
查看更多内容
影响因子：
4.2
作者：
Burt, Richard D.;Thiede, Hanne;Hagan, Holly
通讯作者：
Hagan, Holly
影响因子：
6
作者：
Costenbader, Elizabeth C.;Astone, Nan M.;Latkin, Carl A.
通讯作者：
Latkin, Carl A.
影响因子：
12.7
作者：
El-Bassel, N;Witte, SS;Steinglass, P
通讯作者：
Steinglass, P
DOI：
10.1007/s11524-007-9215-1
发表时间：
2007-09-01
影响因子：
6.6
作者：
Davey-Rothwell, Melissa A.;Latkin, Carl A.
通讯作者：
Latkin, Carl A.
影响因子：
--
作者：
Desgrees-du-Lou, Annabel;Orne-Gliemann, Joanna
通讯作者：
Orne-Gliemann, Joanna