The Impact and Burden of Neurological Sequelae Following Bacterial Meningitis: A Narrative Review.
The Impact and Burden of Neurological Sequelae Following Bacterial Meningitis: A Narrative Review.
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DOI：
10.3390/microorganisms9050900
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发表时间：
2021-04-22
期刊：
影响因子：
4.5
通讯作者：
Dua T
中科院分区：
文献类型：
--
作者：
Schiess N;Groce NE;Dua T
脑膜炎后神经系统后遗症的负担、影响以及社会和经济成本可能对患者、家庭和社区造成毁灭性影响。脑膜炎是大脑和脊髓的急性炎症，导致高死亡率，仅2019年全球就有超过250万例细菌性脑膜炎新发病例和超过236，000例死亡。多达30%的幸存者有某种类型的神经或神经行为后遗症。这些疾病包括癫痫发作、听力和视力丧失、认知障碍、神经运动障碍以及记忆或行为改变。很少有研究记录了长期（超过五年）的后果，或者分析了脑膜炎发生时的年龄是否会导致不良结局。对这些患者及其护理人员的社会经济影响和医疗随访服务需求的了解也很缺乏，特别是在低收入和中等收入国家。在资源有限的情况下，患者及其家属的费用可能非常高。本综述总结了现有的证据，以更好地了解细菌性脑膜炎的神经系统后遗症和致残后果的影响和负担，特别是重点确定现有的差距在中低收入国家。
The burden, impact, and social and economic costs of neurological sequelae following meningitis can be devastating to patients, families and communities. An acute inflammation of the brain and spinal cord, meningitis results in high mortality rates, with over 2.5 million new cases of bacterial meningitis and over 236,000 deaths worldwide in 2019 alone. Up to 30% of survivors have some type of neurological or neuro-behavioural sequelae. These include seizures, hearing and vision loss, cognitive impairment, neuromotor disability and memory or behaviour changes. Few studies have documented the long-term (greater than five years) consequences or have parsed out whether the age at time of meningitis contributes to poor outcome. Knowledge of the socioeconomic impact and demand for medical follow-up services among these patients and their caregivers is also lacking, especially in low- and middle-income countries (LMICs). Within resource-limited settings, the costs incurred by patients and their families can be very high. This review summarises the available evidence to better understand the impact and burden of the neurological sequelae and disabling consequences of bacterial meningitis, with particular focus on identifying existing gaps in LMICs.
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